The Use of Chemogenetic Tools to Analyze Behavior in Non-human Primates
Monday April 06, 2020
8:00 am
-
10:00 am
Eastern Time (ET)
Room 17 A
BEH
NEU
Chair :
Kathleen Grant
Oregon National Primate Research Center (ONPRC)
Verginia Cuzon Carlson
Oregon National Primate Research Center, Oregon Health & Sciences University
The in vivo manipulation of specific brain regions is invaluable for unraveling the circuitry bases of human complex behaviors and disease states. Non-human primates (NHP), like the macaque, are a favorable animal model due to their human homology in cortical expansion sub serving prefrontal associative functions, fine motor control, social context, and physiology. Here, we describe the use of state-of-the-art chemogenetic constructs in awake-behaving NHPs. We also discuss validation methods being developed for non-invasive imaging of viral targeting and expression focusing on PET/fMRI in NHPs.
Speakers
Verginia Cuzon Carlson
- Oregon National Primate Research Center, Oregon Health & Sciences University
Querying the Role Of the Putamen in Cognitive Flexibility and Alcohol Drinking in Rhesus Macaques Using DREADDs
Daicia Allen
- University of California Los Angeles
Chemogenetic Modulation of the Nucleus Accumbens in Ethanol Discrimination
Jessica Raper
- Yerkes National Primate Research Center, Emory University
Development of the Chemogenetic Toolset PSAM/PSEM for Use in Non-human Primates
Takafumi Minamimoto
- National Institutes for Quantum and Radiological Science and Technology
PET-imaging Guided Chemogenetics Dissects Frontal-subcortical Circuits in Monkeys