Chemotactic cytokine (chemokine) receptors are G protein-coupled receptors best known for their role in promoting cell migration by responding to chemokines produced at sites of infection. Although the chemokine/receptor axis is important for normal immune function and wound healing, abnormal chemokine signaling is associated with numerous inflammmatory diseases. The objective of this symposium is to show how understanding the function and signaling pathways activated by chemokine receptors in order to develop better strategies for treating conditions such as cancer, HIV infection, Parkinson's Disease, and cardiovascular disease.