In This Section

Transporters at the Blood-CNS Barriers

Monday April 23, 2018

9:30 am - 12:00 pm Eastern Time (ET)

Room 17A

BEH DCP DMDD NEU DPE TOX

Chair :

Patrick Ronaldson
University of Arizona

Joanne Wang
University of Washington



The delivery of drugs into the central nervous system (CNS) is greatly hindered by the blood-brain barrier (BBB) and the blood-CSF barrier (BCSFB). Emerging evidence suggests that uptake and efflux transporters expressed at these CNS barriers are an important determinant of brain exposure and CNS activity or toxicity of many drugs and neuroactive agents. This symposium will highlight recent advancement in our understanding of the mechanisms, regulation and in vivo significance of ABC and SLC transporters at the BBB and BCSFB.

Speakers

Margareta Hammarlund-Udenaes - Uppsala University

Quantifying Drug Transport at the Blood-Brain Barrier and the Role of Uptake and Efflux Transporters

Patrick Ronaldson - University of Arizona

Targeting Blood-Brain Barrier Transporters for CNS Drug Delivery: Role of Transforming Growth Factor-Beta Signaling

David Smith - University of Michigan

Influence of Peptide Transporter 2 (PEPT2) on the Brain Disposition/Dynamics of Peptides and Peptide-Like Drugs

Joanne Wang - University of Washington

Molecular Pathways of Organic Cation and Anion Transport at the Blood‐CSF Barrier

Tomoka Gose - St. Jude Children's Research Hospital

Is Inhibitor Binding the Sole Requirement in Determining Inhibition of ABCG2 Mediated Transport?