Transporters at the Blood-CNS Barriers
Monday April 23, 2018
9:30 am
-
12:00 pm
Eastern Time (ET)
Room 17A
BEH
DCP
DMDD
NEU
DPE
TOX
Chair :
Patrick Ronaldson
University of Arizona
Joanne Wang
University of Washington
The delivery of drugs into the central nervous system (CNS) is greatly hindered by the blood-brain barrier (BBB) and the blood-CSF barrier (BCSFB). Emerging evidence suggests that uptake and efflux transporters expressed at these CNS barriers are an important determinant of brain exposure and CNS activity or toxicity of many drugs and neuroactive agents. This symposium will highlight recent advancement in our understanding of the mechanisms, regulation and in vivo significance of ABC and SLC transporters at the BBB and BCSFB.
Speakers
Margareta Hammarlund-Udenaes
- Uppsala University
Quantifying Drug Transport at the Blood-Brain Barrier and the Role of Uptake and Efflux Transporters
Patrick Ronaldson
- University of Arizona
Targeting Blood-Brain Barrier Transporters for CNS Drug Delivery: Role of Transforming Growth Factor-Beta Signaling
David Smith
- University of Michigan
Influence of Peptide Transporter 2 (PEPT2) on the Brain Disposition/Dynamics of Peptides and Peptide-Like Drugs
Joanne Wang
- University of Washington
Molecular Pathways of Organic Cation and Anion Transport at the Blood‐CSF Barrier
Tomoka Gose
- St. Jude Children's Research Hospital
Is Inhibitor Binding the Sole Requirement in Determining Inhibition of ABCG2 Mediated Transport?