Epigenetics is defined as the study on heritable changes in gene expression without any alterations in primary DNA sequence. Alterations in epigenetic control mechanisms lead to aberrant gene expression patterns and contribute to the pathogenesis of various diseases, including cancer, cardiovascular, and neurodegenerative diseases.The proposed symposium will introduce the topic of epigenetics and its pivotal role in drug discovery. Symposium will highlight recent advances in epigenetics research and the opportunities in leveraging epigenetic mechanisms to target-based discovery and development. Progress made in the application of the field to the development of potential therapeutics to areas beyond cancer will be discussed.