Computational Approaches to G Protein-Coupled Receptor Structure and Function
Tuesday April 24, 2018
3:30 pm
-
6:00 pm
Eastern Time (ET)
Room 17A
CVP
DDD
MP
NEU
DPE
Chair :
Alexandra Conibear
University of Bristol
Eamonn Kelly
University of Bristol
Sponsored by British Pharmacological Society (BPS)
This symposium aims to showcase how advanced computing can be used to understand GPCR structure and function and so the development of novel drugs. GPCRs play diverse roles in biological processes and are linked to a wide range of disease areas. As our understanding of GPCRs increases through use of techniques such as X-ray crystallography and molecular dynamics simulations, the complexity of the drug development process also increases. A major thrust of the symposium is to explain these techniques in a user-friendly manner such that they can be considered as a realistic option for today’s experimental pharmacologist.
Speakers
Jonathan Mason
- Heptares Therapeutics Ltd
X-Ray Structures of GPCRs Provide Insights into New Binding Sites for Drug Discovery
Ron Dror
- Stanford University
Molecular Simulation and Machine Learning for the Design of Finely Tuned Drugs
Irina Tikhonova
- Queen's University Belfast
The Role of Dynamic Conformational Ensembles in GPCR Function
Chris de Graaf
- VU University Amsterdam
Computational Medicinal Chemistry Approaches to GPCR Drug Discovery
Marc von Zastrow
- University of California, San Francisco
Probing GPCR Cell Biology by Quantitative Proteomics