EB2010 Division of Toxicology Sponsored and Co-sponsored Symposia

Division sponsored symposia

1. Regulating the regulators: redox regulation, stress response proteins and apoptosis. Chair: D. St. Clair. Tue. AM
   1. Introduction to the connections among cellular redox status, mitochondria and transcription response. D. St. Clair. University of Kentucky
   2. p53 Regulates mitochondrial function. P. M. Hwang. NHLBI, NIH
   3. ROS and p53 modulators in cancer-specific apoptosis. S. W. Lee. Harvard Medical School
   4. SIRT3 is a mitochondrial tumor suppressor gene required for maintenance of mitochondrial integrity and oxidative metabolism during stress. D. Gius. Vanderbilt University
   5. Mitochondria: novel regulation of the Keap1/Nrf-2 antioxidant pathway. A. Landar. University of Alabama at Birmingham
   6. The bi-directional role of p53 on MnSOD expression. S. Dhar. University of Kentucky
2. Division for Toxicology Symposium: ABC transporters, their role in physiology, toxicology and cancer. Chair: J. Schuetz. Tue. PM
   1. Introduction. J. Schuetz. St. Jude Children’s Hospital
   2. Transcriptional regulation of hepatobiliary transporters. C. D. Klaassen. University of Kansas Medical Center
   3. Applying principles derived from laboratory studies to multidrug resistance in human cancers. M. M. Gottesman. NCI, NIH
   4. Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy. B. Bauer. College of Pharmacy, University of Minnesota at Duluth
   5. The contribution of ABC transporters to drug resistance in a realistic mouse mammary tumor model. P. Borst. University of Amsterdam
3. Role of mitochondria in drug hepatotoxicity: a tale of stress. Chair: N. Kaplowitz. Wed. AM
   1. Introduction. N. Kaplowitz. University of Southern California
   2. Compartmentation of oxidative stress defense in mitochondria: implications of drug toxicity. D. Jones. Emory University School of Medicine
   3. Mitochondrial permeability transition – target and executioner in DILI. J.J. Lemasters. Medical University of South Carolina
   4. Interplay of signal transduction and mitochondria in the acetaminophen model. D. Han. University of Southern California

Division co-sponsored symposia

1. Orphan cytochrome P450 and other drug metabolizing enzymes. Chair: F. P. Guengerich. Sun. AM
   1. Introduction. F. P. Guengerich. Vanderbilt University School of Medicine
   2. Overview: The general problem of characterizing proteins of unknown function. F. P. Guengerich
   3. Transgenic mouse approaches to P450 function. F. J. Gonzalez. NCI, NIH
   4. Use of humanized mice in the study of the function of human UGT enzymes. J. C. Stevens. Pfizer Inc.
   5. Determinants of variability in divalproex sodium (VPA) glucuronidation in children. J. S. Leeder. Children’s Mercy Hospitals and Clinics.
   6. In vitro LC-MS approaches to deorphanization of cytochrome P450 enzymes. Z. Tang. Vanderbilt University School of Medicine
2. Introduction of drug safety (pharmacovigilance) into curricula. Chair: G. Dunaway and J. Strandhoy. Mon. AM
   1. Introduction of pharmacovigilance. G. Dunaway. Southern Illinois University School of Medicine
   2. Mechanisms of common and important adverse drug reactions. J. Strandhoy. Wake Forest University School of Medicine
   3. The role of the FDA in drug safety education. C. D. Furberg. Wake Forest University School of Medicine
   4. Models for introduction of pharmacovigilance into the curriculum. C. L. Faingold. Southern Illinois University School of Medicine
   5. Careers in drug safety. S. W. Mittelstadt. Abbott Laboratories
3. Integrating genetics, genomics and pharmacology: how the pharmacogenomics knowledge base catalyzes pharmacogenomic research and translational medicine. Chair: R. Altman and A. Gaedigk
   1. Introduction.
   2. The PharmGKB database and the pharmacogenetics research network: what it can do for your research. R. Altman. Stanford University
   3. Genome-wide association studies in pharmacogenomics. E. Dolan. University of Chicago
   4. Pharmacogenomics and membrane transporters: a critical component of drug response. D. Kroetz. UCSF
   5. Curation process at PharmGKB. L. Gong. Stanford University