G Protein Signaling in Regulation of Metabolism and Diabetes
Saturday April 04, 2020
2:00 pm
-
4:00 pm
Eastern Time (ET)
Room 17 A
BEH
CVP
DDD
MP
Chair :
Adriano Marchese
Medical College of Wisconsin
Vladlen Slepak
University of Miami
G protein-coupled receptors (GPCRs) activate signaling pathways in the pancreas, skeletal muscle, the CNS and other tissues to regulate metabolism. This signaling is important in normal physiology, but its dysregulation can lead to diseases such as diabetes and obesity, which are the major contributing factors to cardiovascular disease. Talks in this session will address recently emerged unique and understudied aspects of G protein signaling in metabolism. The session will provide a unifying theme by which targeting novel aspects of GPCR signaling has the potential to be therapeutically relevant in diabetes and obesity.
Speakers
Vladlen Slepak
- University of Miami
The Role of the Gbeta5-R7 RGS Protein Complex in Metabolism and Hormone Secretion
Michelle Kimple
- University of Wisconsin
Beta-cell EP3 and Gαz Signaling and Susceptibility to Diabetes: A Beneficial Adaptation or a Dysfunctional Consequence?
Jurgen Wess
- NIDDK, Molecular Signaling Section, Laboratory of Bioorganic Chemistry
Skeletal Muscle-specific Activation of Gq Signaling in vivo greatly Improves Impaired Glucose Homeostasis
Graeme Milligan
- University of Glasgow
Chemogenetic Approaches to Define Metabolic Roles of Short Chain Fatty Acids
Daniela Dengler
- Sanford Burnham Prebys Medical Discovery Institute
Identification and Characterization of Dual-Acting Small Molecule Modulators targeting Secretin
Receptors
Darby Peter
- UW-Madison
Beta-cell-specific Loss of the Inhibitory G protein, Gα, has Sex-dependent Effects on Development and
Pathophysiology of Type 1 Diabetes