Many neuropeptides have been found to contribute to a variety of motivated behaviors including arousal, feeding, and reward. This symposium will introduce some new neuropeptides that have recently been determined to facilitate these motivated behaviors including hypocretins, urotensin, nociceptins, neurotensin, and ProSAAS-derived peptides. These studies have used a variety of techniques including behavioral and molecular pharmacology, optogenetics and chemogenetics. Each of these presentations will give new insights into the complexity of arousal, feeding, and reward-related behaviors and open up the possibility of developing novel therapeutics to treat a variety of neuropsychiatric disorders, including addiction.