Targeting Autophagy in Cancer
Saturday April 02, 2022
11:00 am
-
12:30 pm
Eastern Time (ET)
111 AB
DCP
Chair :
Andrew Thorburn
Univ of Colorado Anschutz Medical Campus
Rushika Perera
University of California San Francisco
Christina Towers
Salk Institute
This session will discuss recent advances in targeting autophagy as a treatment for cancer. Four leading investigators will discuss recent advances in the field that explain how autophagy modulation in cancer can affect anti-tumor immunity, how lysosomes regulate cancer behavior, the development of new autophagy inhibitors that target the lysosome in novel ways, and how cancer cell resistance to autophagy inhibitors can arise and may be circumvented.
Speakers
Eileen White
- Rutgers University
Role of Autophagy in Suppressing the Anti-cancer Immune Response
This talk will discuss mechanisms by which the autophagy machinery in tumor cells and host tissues modulates anti-tumor immune responses
Rushika Perera
- University of California San Francisco
New Features and Functions of Cancer Lysosomes
This talk will discuss recent advances in understanding how lysosomes in cancer cells affect tumor behavior
Ravi Amaravadi
- Univ. of Pennsylvania
Developing Autophagy Inhibitors for Cancer Clinical Trials
This talk will discuss the development of new autophagy inhibitors and their application in clinical trials
Christina Towers
- Salk Institute
Mechanisms to Circumvent Autophagy Inhibition in Cancer Cells
This talk will discuss how cancer cells adapt to circumvent autophagy inhibition and how this may be leveraged to better treat cancer and avoid therapy resistance.