Novel and Integrated Intestine-liver Crosstalk on Hepatic Xenobiotic Metabolism
Sunday April 05, 2020
8:00 am
-
10:00 am
Eastern Time (ET)
Room 15 A
DMDD
TOX
Chair :
Hongbing Wang
University of Maryland
Grace Guo
Rutgers Univ - Ernest Mario Sch of Pharmacology
The liver stays in the center of drug metabolism that is regulated by xenobiotic receptors and endocrine factors during development, physiology and pathology. The intestine and liver are closely interacted and a role of intestine derived factors is emerging in critically regulating the endobiotic and xenobiotic metabolism in the liver. Novel medicine or technologies to treat human diseases will be developed inspired by these interactions. This symposium will bring the best knowledge, novel in vitro and in vivo technology, and application of intestine-liver crosstalk to audience with interest in novel drug development and pharmacology.
Speakers
Andrew Patterson
- Penn State University
The Aryl Hydrocarbon Receptor as a Moderator of Host-microbiota Communication
Masahiko Negishi
- National Institute of Environmental Health Sciences (NIEHS), NIH
Activation of Xenobiotic Receptor by Endocrine Signaling Pathways
Shiew-Mei Huang
- US Food and Drug Administration
Emerging Role of Organ-on-a-Chip Technologies in Quantitative Clinical Pharmacology Evaluation
Murat Cirit
- Javelin Biotech
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies
Guo Zhong
- University of Washington
Postnatal Loss of Cyp26a1 and Cyp26b1 in Mice causes Impaired retinoid Homeostasis in Multiple Organs