New Roles and Mechanisms of RGS Proteins in Physiology and Disease
Monday April 08, 2019
8:00 am
-
10:00 am
Eastern Time (ET)
Room W205 BC
DDD
MP
Chair :
Kirill Martemyanov
The Scripps Research Institute
Rory Fisher
University of Iowa Carver College of Medicine
The discovery of Regulators of G Protein Signaling (RGS) proteins, over 20 years ago, fundamentally transformed our views of GPCR signaling. RGS proteins are now well established as GTPase-accelerating proteins promoting inactivation of G proteins to control the magnitude and duration of GPCR-initiated responses. Recent years witnessed tremendous progress in uncovering novel mechanistic details and non-canonical roles of RGS proteins catalyzed by development of relevant genetic mouse models. This symposium explores the latest advances in fundamental mechanisms by which RGS proteins orchestrate cellular signaling, their role in physiology, disease and drug discovery efforts.
Speakers
Rory Fisher
- University of Iowa Carver College of Medicine
Two Birds, One Stone: G protein-dependent and -independent Roles of RGS6
Ikuo Masuho
- The Scripps Research Institute
G Protein Selectivity and Human Genetic Variants of RGS Proteins in Health and Disease
Benita Sjogren
- Purdue University
Strategies for Targeting RGS Protein Regulation
Venetia Zachariou
- Icahn School of Medicine at Mount Sinai
RGSz1 Modulates Symptoms of Long term Pain and the Actions of Opioid Analgesics
Kirk Druey
- NIAID/NIH
RGS Proteins as Therapeutic Targets in Asthma
Carolina Montanez-Miranda
- Emory University
Characterizing a Novel RGS14:MyosinV/VI Interaction in Brain
Ram Kandasamy
- University of Michigan Medical School
Loss of RGS Control at Gαo Reveals a Balance Between Nociceptin and Mu-opioid Receptor Systems
Vladlen Slepak
- University of Miami Sch. Med.
Gbeta5-R7 Regulator of G Protein Signaling Complex is a Positive Regulator of Insulin Secretion
Allison Anderson
- University of Minnesota
Differential Impact of RGS6 on GIRK-dependent Muscarinic and Adenosine Receptor Signaling in Mouse Sinoatrial Nodal Cells
Menbere Wendimu
- University of Georgia
A Novel Interaction between Regulator of G-protein Signaling (RGS10) and STIM2 Identifies New Mechanism for the Regulation of COX-2 in Microglia