Dr. Zahniser pioneered research elaborating our understanding of how dopamine and glutamate contribute to individual differences in cocaine-induced brain plasticity and addiction-like behavior, and how dopamine transporters are rapidly regulated. Her findings underscore the overall importance of dopamine transporters in contributing to enhanced vulnerability to cocaine addiction and relapse. Dr. Zahniser was strongly committed to mentoring young scientists, and to ASPET. In tribute of her many accomplishments, this symposium captures the most recent advances in understanding dopamine transporter function and regulation, and its important role in health, disease, and addiction. Importantly, this symposium highlights novel targets for treating dopamine-linked pathologies.