Education in the health sciences has undergone a dramatic evolution in response to changing board exam formats. Many of these exam questions now require test takers to apply an integrated knowledge of biomedical and behavioral science to solve clinical problems. This change has necessitated the development of teaching methods that are better at guiding students toward mastery of these minimal competency expectations. This symposium will present several unique teaching methodologies used to promote cognitive integration of basic and clinical sciences. Attendees will gain first-hand experience with these pedagogies by working cases in small and large group discussions.