Mechanisms of Drug-Induced Liver Injury: From Bedside to Bench and Back
Saturday April 06, 2019
11:00 am
-
1:00 pm
Eastern Time (ET)
Room W206 B
DDD
DMDD
TOX
TCP
Chair :
Neil Kaplowitz
Keck School of Medicine of USC
Xiaochao Ma
University of Pittsburgh
Drug-induced liver injury (DILI) remains one of the major concerns for drug developers, regulators, healthcare providers and patients. Unfortunately, the mechanisms of DILI are largely unknown. This symposium will highlight novel insights into the mechanisms of DILI from the perspectives of metabolomics, genomics, and cell signaling pathways. This session will also discuss the potential applications of novel findings from the preclinical studies of DILI for the management of DILI in the clinic.
Speakers
Neil Kaplowitz
- Keck School of Medicine of USC
Novel Insights into the Role of Cell Signaling Pathways in Drug-Induced Liver Injury
Xiaochao Ma
- University of Pittsburgh
Role of Human Pregnane X Receptor in DILI: Drug Metabolism and Beyond
Ann Daly
- Institute of Cellular Medicine Newcastle University, UK
Genetic Associations in Drug-induced Liver Injury
Pranoti Mandrekar
- University of Massachusetts Medical School
Translational Approaches to Develop Targeted Therapies in Liver Diseases
Liming Chen
- University of Connecticut
Impact on Acetaminophen-induced Hepatotoxicity by Long Non-coding RNAs HNF1α-AS1 and HNF4α-AS1 in HepaRG Cells
Lan Zhang
- University of Louisville School of Medicine
Lactobacillus rhamnosus GG Supernatant Prevents Acute Alcohol-induced Liver Steatosis and Injury through ER Stress and Autophagy-mediated Signaling Pathways