G Protein Signaling in Regulation of Metabolism and Diabetes
Thursday April 29, 2021
10:00 am
-
11:30 am
Eastern Time (ET)
View session on the EB Virtual Platform (EB registration required)
CVP
DDD
MP
Chair :
Vladlen Slepak
University of Miami
G protein-coupled receptors (GPCRs) activate signaling pathways in the CNS, pancreas, fat and other tissues to regulate metabolism. This signaling is important in normal physiology, and its dysregulation can lead to disease such as diabetes and obesity, which are the major contributing factors to cardiovascular and other disorders. Talks in this session will address recently emerged and understudied aspects of G protein signaling, providing a unifying theme of how targeting novel mechanisms has the potential to be therapeutically relevant in metabolic disorders.
Speakers
Vladlen Slepak
- University of Miami
The Role of the Gbeta5-R7 RGS Protein Complex in Metabolism and Hormone Secretion
Analysis of global and inducible knockout of the Gnb5 gene reveals non-canonical function of the Gbeta5-RGS complex in pancreatic beta cells/insulin secretion and in neuronal control of body weight.
Michelle Kimple
- University of Wisconsin
The Function and Dysfunction of Pancreatic β-cell EP3 Signaling in the Progression to Type 2 Diabetes
Novel ideas about signaling in endocrine pancreas will be presented.
Jurgen Wess
- NIH, NIDDK
DREADD Technology Offers Novel Insights Into Adipocyte Function
Much of the talk will be based on the application of DREADD technology to discover GPCR mechanisms in regulation of metabolism.
Graeme Milligan
- University of Glasgow
Chemogenetic Approaches to Define Metabolic Roles of Short Chain Fatty Acids
At the physiological level, the talk will concern the gut-brain connection via fatty acid-sensing GPCRs.
Matthew Varney
- Thomas Jefferson University
G Protein-Coupled Receptor Kinase 6 (GRK6) Regulation of Insulin Processing and Secretion
Provide a brief description of your talk appropriate for publication. Limit your talk description to 2-3 sentences.
Daniela Dengler
- SBP Medical Discovery Institute
Discovery of Small Molecule Modulators targeting Secretin Receptors
Provide a brief description of your talk appropriate for publication. Limit your talk description to 2-3 sentences.