Behavioral Pharmacology of Biased Agonists
Sunday April 05, 2020
3:00 pm
-
5:00 pm
Eastern Time (ET)
Room 17 A
BEH
DDD
MP
NEU
Chair :
William Fantegrossi
University of Arkansas for Medical Sciences
Development of “biased ligands” preferentially activating specific signaling pathways by stabilizing subsets of receptor conformations that invoke distinct G protein-dependent or –independent signaling are underway. Development of novel analgesics acting via CB1, μ-, δ- and κ-opioid receptors is focused on identification of G protein-selective compounds that are devoid of β-arrestin 2 recruitment because evidence suggests that this may reduce adverse effects. Results of these efforts appear promising in vitro, but in vivo confirmation of biased agonism is relatively rare. This symposium will survey biased agonism across pharmacological classes, focusing on behavioral effects which may differentiate them from traditional unbiased agonists.
Speakers
Mei-Chuan (Holden) Ko
- Wake Forest University
In vivo Evaluation of G Protein Biased Agonists at Mu-opioid Receptors in Non-human Primates
Paul Prather
- University of Arkansas for Medical Sciences
Characterization of Structurally Novel G Protein Biased CB1 Agonists
Mehrdad Shamloo
- Stanford University School of Medicine
Biased Agonism at Beta-1 Adrenergic Receptors as a Novel Treatment Strategy for Alzheimer's Disease
Charles Nichols
- LSU New Orleans
Functional Selectivity at the Serotonin 5-HT2A Receptor