Adhesion GPCRs (AGPCRs) are critical regulators of nervous system development and physiology. Most AGPCRs are considered understudied by the NIH, yet they comprise ~10% of all non-sensory GPCRs. Rapid developments have ensued including elucidation of a common activation mechanism, recognition that AGPCRs control glial progenitor differentiation and nerve myelination, and act as trans-synaptic connectors. The potential of AGPCRs as therapeutic targets has gained traction through discovery of small molecule receptor modulators. The symposium brings together a collection of experts in different facets of AGPCR neurobiology who will present cutting edge topics.