Give a Day of Service to Boston at EB 2015

10:00 AM–3:00 PM 

Since 2009, ASPET members attending Experimental Biology (EB) have given a day of volunteer service in the local communities  such as New Orleans, Pasadena, Washington DC, and San Diego.

Volunteer activities have ranged from home construction to painting, cleaning, stocking, food preparation, and food service. ASPET's division for behavioral pharmacology is again sponsoring a volunteer opportunity at EB 2015 in Boston.

On Friday, 27 March 2015, we will spend the day at Cradles to Crayons, helping the children of Boston. Volunteers will also be able to prepare materials prior to the volunteer day such as personalized well-wisher notes that are placed in backpacks given to children at the start of the school year.

Cradles to Crayons provides children from birth through age 12 living in homeless or low-income situations with the essential items they need to thrive at home, at school, and at play.

If you want to volunteer, please contact Charles P. France at your earliest convenience.

Email: france@uthscsa.edu
Tel: 210 567 6969
Fax: 210 567 0104 

Space is limited and further details will be provided to those who volunteer.

Behavioral Pharmacology Society Dinner

Westin Boston Waterfront Hotel
6:00 pm–10:00 pm
By Invitation only—Separate pre-registration required 

Behavioral Pharmacology Society Meeting

Westin Boston Waterfront Hotel
8:00 am–6:00 pm
By Invitation only—Separate pre-registration required 

Speed Networking for Careers Beyond the Academic Bench

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Janet E. Clark—Nat’l Inst. of Mental Hlth./NIH 
Paul McGonigle—Drexel Univ. Coll. of Med.

Sponsored by the Divisions for:  

• Pharmacology Education 
• Behavioral Pharmacology  
• Cardiovascular Pharmacology 
• Drug Discovery and Development  
• Drug Metabolism  
• Translational and Clinical Pharmacology  
• Molecular Pharmacology  
• Neuropharmacology 
• Toxicology  

Biomedical Careers in the Pharmaceutical Industry
Janet Clark—NIMH/NIH

Career Paths in the Biotechnology Industry and Startup Companies
Paul McGonigle—Drexel Univ. Coll. of Med.

Pursuing a Career in Intellectual Property, Technology Transfer and Business Development in the Biomedical Sciences
Jane Amara—Boston Children’s Hosp.

Science Policy as a Biomedical Career Path
Meredith Fox—NIMH/NIH

The Scientific Review Officer and Program Officer Career Paths
Aaron Pawlyk—NIDDK/NIH

Directing Virtual Research
Michael Wood—Astrazeneca

Science: A Constant Rewrite
Christopher Thomas—NINDS/NIH

2015 Teaching Institute: Training Students for Teaching Careers

Boston Convention Center
12:00 pm–2:30 pm

Chairs:
Kelly Karpa—Penn State Univ. Coll. of Med.
Klarissa Hardy—Lipscomb Univ. Coll. Pharmacy

Why Train Our Trainees to Train?
Wayne T. McCormack—Univ. of Florida Coll. of Med.

Giving STEM Doctoral Students a FAST (Future Academic Scholars in Teaching) Start for Academic Careers
Henry (Rique) Campa, III—Michigan State Univ..

Your Future Craft: How Gaining Experience in the Classroom is Essential for Life Outside the Lab
Johnathan Neiswinger—NIA/NIH

Mentoring Future Educators
Cynthia Fuhrmann—Univ. of Massachusetts Med. Sch.

Graduate Student-Postdoctoral Colloquium: How to Get Started

Boston Convention Center
2:45 pm–5:15 pm

Co-Chairs: 
Ann Hanna-Mitchell—Case Western Reserve Univ.
Helmut Gottlieb—Feik Sch. of Pharmacy 

Who Owns the Data I Generated and How Do I Transition from Graduate School/Postdoctoral to an Independent Career?
Lynn Wecker—South Florida Morsani Coll. of Med.

10 Things I Wish I Had Known When I Graduated
Helmut Gottlieb—Feik Sch. of Pharmacy
Uyen Chu—Univ. of Wisconsin-Madison

Working for America
Dale Birkle Dreer—Nat. Ctr. for Complementary and Alternative Medicine / NIH

Working with Pharmaceutical Companies: What Industry Wants from You
Lawrence P. Carter—Jazz Pharmaceuticals

Table Breakout Sessions
Representatives from academia, federal, industry, and other career disciplines

ASPET Business Meeting

Boston Convention Center
6:00 pm–7:30 pm

ASPET Opening and Awards Reception

Sponsored by: Optivia Biotechnology
Boston Convention Center
7:30 pm–9:30 pm

Diversity Mentoring Breakfast

Westin Boston Waterfront
7:30 am–9:30 am
Pharmacologists: Leading the Prescription for Change in Medical Education
Keynote Speaker: Jayne Reuben—Univ. of South Carolina Greenville Sch. of Med.
By Invitation only 

Journal of Pharmacology and Experimental Therapeutics Associate Editor's Breakfast Meeting

Westin Boston Waterfront
7:30 am–9:30 am

ASPET Presidential Symposium: Navigating the Future of Biomedical Research

Boston Convention Center
9:30 am–12:00 pm

Chair: Annette E. Fleckenstein—Univ. of Utah

Sponsored by the Divisions for: 

• Behavioral Pharmacology 
• Cardiovascular Pharmacology 
• Drug Discovery and Development 
• Drug Metabolism 
• Translational and Clinical Pharmacology 
• Molecular Pharmacology 
• Neuropharmacology 
• Pharmacology Education 
• Toxicology  

Stabilizing a Productive but Structurally Unstable Research System
Michael S. Teitelbaum—Labor and Worklife Program, Harvard Law Sch.

Training Future Biomedical Researchers: Challenges and Opportunities
Nancy L. Desmond—NIMH/NIH

Assuring a Bright Future for Biomedical Research
Shai Silberberg—NINDS/NIH

Navigating the Future of Drug Development: Calm Seas or Stormy Weather?
Phil Skolnick—NIDA/NIH

New Directions in Supporting Science
Michael E. Rogers—NIGMS/NIH

Bile Acids and Liver Disease in Pregnant Women and Neonates

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Lauren M. Aleksunes—Rutgers Univ.
Grace L. Guo—Rutgers Univ.

Sponsored by the Divisions for: 

• Toxicology 
• Translational and Clinical Pharmacology 
• Drug Metabolism 
• Molecular Pharmacology 

Neonatal Consequences of Maternal Intrahepatic Cholestasis
John Schuetz—St. Jude Children’s Res. Hosp.

Maternal Enterohepatic Bile Acid Signaling: Priming for Cholestatic Disease
Lauren Aleksunes—Rutgers Univ.

Perinatal Pharmacology of the FXR Nuclear Receptor
Wen Xie—Univ. of Pittsburgh

FXR Signaling in Total Parenteral Nutrition-Associated Liver Disease
Grace Guo—Rutgers Univ.

Pregnancy-Related Hormones Modulate Protein Expression of Hepatic DMEs and Transporters in HepaRG Cells
Muhammad Farooq—Univ. of Washington

Ion Channel Drug Discovery-Advancements and Current Challenges

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Sujay V. Kharade—Vanderbilt Univ. Med. Ctr.
Michael F. Jarvis—AbbVie

Sponsored by the Divisions for: 

• Drug Discovery and Development 
• Cardiovascular Pharmacology 
• Translational and Clinical Pharmacology 
• Molecular Pharmacology 

Ion Channel Drug Discovery: Challenges and Future Directions
Douglas Krafte—Neusentis/Pfizer

Ion Channel Screening Technologies
O.B. McManus—Essen Bioscience, Inc.

Antibody Therapeutics Targeting Ion Channels: Are We There Yet?
Narender Gavva—Amgen

Targeting Inward Rectifier Potassium (Kir) Channels to Treat Cardiovascular/Metabolic Disorders
Sujay Kharade—Vanderbilt Univ. Med. Ctr.

Emerging Roles of Trace Amine Associated Receptor 1 (TAAR1) in Drug Abuse and Mental Disorders

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Jun-Xu Li—Univ. at Buffalo, SUNY
Gregory M. Miller—Harvard Med. Sch./New England Primate Res. Ctr.

Sponsored by the Divisions for: 

• Behavioral Pharmacology 
• Molecular Pharmacology 
• Neuropharmacology 
• Drug Discovery and Development 
• Translational and Clinical Pharmacology 

A Trace Amine-Associated Receptor Mechanism of Action Distinguishes Methamphetamine from Cocaine
David Grandy—Oregon Hlth. & Sci. Univ.

Trace Amine Associated Receptor 1 is Implicated in the Central and Immunological Effects of Drugs of Abuse
Gregory Miller—Harvard Med. Sch./New England Primate Res. Ctr.

Frontostriatal Dysfunction in Mice Lacking TAAR1
Stefano Espinoza—Italian Inst. Of Tech.

Selective TAAR1 Agonists as Potential Therapeutic Drugs for Psychiatric and Metabolic Disorders
Marius C. Hoener—F. Hoffman-La Roche, Ltd.

The TAAR 1 Agonist RO5263397 Attenuates the Abuse-Related Effects of Cocaine in Rats
Jun-Xu Li—Univ. at Buffalo, SUNY

Emerging Regenerative Therapies in Pulmonary Disease

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Yuru Liu—Univ. of Illinois at Chicago
Jalees Rehman—Univ. of Illinois at Chicago

Sponsored by the Divisions for: 

• Translational and Clinical Pharmacology 
• Toxicology 
• Molecular Pharmacology 
• Cardiovascular Pharmacology  

The Role of Endogenous Regenerative Epithelial Cells in Alveolar Repair
Yuru Liu—Univ. of Illinois at Chicago

Modeling Human Lung Development Using Pluripotent Stem Cells 
Sarah X.L. Huang—Columbia Univ. Med. Ctr.

Regenerating the Vasculature in Lung Disease
Jalees Rehman—Univ. of Illinois at Chicago

Mesenchymal Stromal Cells: Biology and Therapeutic Potential for ARDS
Michael Matthay—UCSF Sch. Of Med.

Translating Regenerative Therapies: Opportunities and Challenges
Panel Discussion

The Role of Protein-protein and Protein-membrane Interactions on P450 Function

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Wayne L. Backes—LSU Hlth. Sci. Ctr., New Orleans, LA
Jeffrey P. Jones—Washington State Univ.

Sponsored by the Divisions for: 

• Drug Metabolism 
• Molecular Pharmacology  

Introduction
Wayne Backes—LSU Hlth. Sci. Ctr., New Orleans, LA

Positioning of Microsomal CYPs and Drugs in Lipid Bilayers
Michal Otyepka—Palacky Univ. Olomouc, Czech Republic

The Role of the Endoplasmic Reticulum in Modulating P450 Function
James R. Reed—LSU Hlth. Sci. Ctr., New Orleans, LA

Human Cytochrome P450 Interactions with Catalytic Protein Partners
Emily Scott—University of Kansas

Role of NADPH-Cytochrome P450 Reductose and Cytochrome b5 as Electron Donors to Cytochrome P450
C. Roland Wolf—University of Dundee

Deconvoluting the Dance: P450 Reaction Mapping Via Super-Resolution Imaging
Sara C. Humphreys—Washington State Univ.

ASPET Poster Presentations

Boston Convention & Exhibition Center
12:30 pm–2:30 pm

Board of Publications Trustees Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Division for Cardiovascular Pharmacology Executive Committee Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Division for Drug Discovery and Development Executive Committee Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Division for Drug Metabolism Executive Committee Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Julius Axelrod Award in Pharmacology Lecture

Boston Convention Center
2:00 pm–2:50 pm
Jeffrey L. Benovic—Thomas Jefferson Univ.
Arresting Developments in Receptor Signaling 

Julius Axelrod Symposium: The Ins and Outs of G Protein-Coupled Receptor Signaling

Supported by the John V. Croker Fund
Boston Convention Center
3:00 pm–5:30 pm

Chair: Jeffrey L. Benovic—Thomas Jefferson Univ.

Structure, Function, and Inhibition of G Protein-coupled Receptor Kinases
John Tesmer—Univ. of Mich Med. Sch.

Arrestin-GPCR Interactions: Molecular Mechanisms and Targeted Re-engineering
Vsevolod Gurevich—Vanderbilt Univ. Med. Ctr.

Regulation of GPCR Trafficking and Signaling by Ubiquitin
Adriano Marchese—Loyola Univ.

Spatial and Temporal Specificity in Cellular GPCR Signaling
Mark von Zastrow—UCSF Sch. of Med.

Division for Pharmacology Education Programming: Active Learning—What’s up with the Flipping Classroom

Sponsored by: IAMSE
Westin Boston Waterfront
3:00 pm–5:30 pm

Chair: John L. Szarek—Commonwealth Med. Coll.

Sponsored by the Divisions for: 

• Pharmacology Education 
• Translational and Clinical Pharmacology 
• Cardiovascular Pharmacology 
• Molecular Pharmacology 
• Behavioral Pharmacology 
• Neuropharmacology 

Doing is Better: The Concept of Active Learning and the Flipped Classroom
William B. Jeffries—Univ. of Vermont College of Medicine

The Continuum from a Single Active Learning Technique to the Flipped Classroom: Implementation along the Continuum
John L. Szarek—Commonwealth Med. Coll.

Does it Work: Evaluating Your Flipped Classroom Experiences and Scholarship
Kathryn Huggett—Creighton Univ. School of Medicine

Facilitated Small Group Activities 

Taking it Back Home: Limitations, Myths and Misunderstandings about the Active Learning and the Flipped Classroom
Panel: William B. Jeffries, John L. Szarek, Kathryn Huggett

Interindividual Variability in CYP-Mediated Drug Metabolism

Boston Convention Center
3:00 pm–5:30 pm

Chairs:
Hyunyoung Jeong—Univ. of Illinois at Chicago
Timothy S. Tracy—Univ. of Kentucky

Sponsored by the Divisions for: 

• Drug Metabolism 
• Toxicology 
• Drug Discovery and Development 
• Molecular Pharmacology 
• Translational and Clinical Pharmacology 

Genetic Predictors of Human Liver CYP Expression & Activity
Erin Schuetz—St. Jude Children’s Res. Hosp.

Impact of Neonatal Drug Exposure on Interindividual Variations of P450-Mediated Drug Metabolism
Xiaobo Zhong—Univ. of Connecticut

Interindividual Variability in CYP2D6-Mediated Drug Metabolism
Hyunyoung (Young) Jeong—Univ. of Illinois, Chicago

Biomarkers of CYP activity using Metabolomic Approaches
Yvonne Lin—Univ. of Washington, Seattle

Vascular Stiffness, a Novel Therapeutic Approach for Hypertension

Boston Convention Center
3:00 pm–5:30 pm

Chair: Stephen F. Vatner—Rutgers University

Sponsored by the Divisions for: 

• Cardiovascular Pharmacology 
• Drug Discovery and Development 
• Molecular Pharmacology 
• Translational and Clinical Pharmacology 

Vascular Stiffness, a Novel Therapeutic Approach for Hypertension
Ernesto L. Schiffrin—Sir Mortimer B. Davis-Jewish Gen. Hosp. and McGill Univ.

Regional Vascular Stiffness in Aging and Hypertension 
Stephen F. Vatner—Rutgers Univ., New Jersey Med. Sch.

Increased Vascular Smooth Muscle Stiffness: A Novel Mechanism for Aortic Stiffness in Hypertension
Gerald A. Meininger—Univ. of Missouri

Subcellular Targets for the Treatment of Aging-Induced Increases in Vascular Stiffness
Kathleen Morgan—Sargent College, Boston Univ.

NIH Vascular Biology and Hypertension Branch Interest in Vascular Stiffness
Young S. Oh—NHLBI/NIH

Future Directions and Controversies in the Field of Vascular Stiffness—
El. Schiffrin, S.F. Vatner, G.A. Meininger, K. Morgan, Y. Oh

Elucidating the Molecular Underpinnings of Behavior Using Pharmacological Knock-In Mouse Models

Boston Convention Center
3:00 pm–5:30 pm

Chair: Randy D. Blakely—Vanderbilt Univ. Sch. of Med.

Sponsored by the Divisions for: 

• Neuropharmacology 
• Behavioral Pharmacology 
• Molecular Pharmacology 
• Translational and Clinical Pharmacology 
• Drug Discovery and Development 

Up in Smoke: Using a Gain-of-Function Gating Mutation in an Ion Channel to Study Nicotine Addiction
Ryan Drenan—Purdue Univ.

Beyond Benzodiazepines: Novel Therapeutic Potential of GABA_A Receptor Subtypes Revealed by Knock-in Point Mutations Selectively Ablating Allosteric Modulation
Uwe Rudolph—McLean Hospital and Harvard Med. Sch.

The Highs and Lows of Cocaine: Insights into Cocaine Actions in Reward Pathways Using a Knock-in Dopamine Transporter Mouse Model
Howard Gu—Ohio State Univ.

Cocaine Around the Clock: SERT Met172 Mice Elucidate the Serotonergic Basis of Cocaine Actions on Circadian Physiology and Behavior
Rebecca Prosser—Univ. of Tennessee

Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine as Revealed Using the SERT M172 Mouse
Alex G. Nackenoff—Vanderbilt Univ.

Nanotoxicology: Small Particles, Big Concerns

Boston Convention Center
3:00 pm–5:30 pm

Chairs:
Jeffrey S. Fedan—Nat’l Inst. for Occupational Safety and Hlth.
Dale W. Porter—Nat’l Inst. for Occupational Safety and Hlth.

Sponsored by the Divisions for: 

• Toxicology 
• Drug Metabolism 
• Cardiovascular Pharmacology 
• Translational and Clinical Pharmacology 

Introduction
Jeffrey S. Fedan—NIOSH

From Micro- to Nano-Particles; Historical Prespectives and Concepts 
Günter Oberdörster—Univ. of Rochester Sch. of Medicine & Dentistry

Nanoparticles: Structure, Biophysics, Chemistry and Reactions in Biological Tissues
Andrij Holian—Univ. of Montana

Multi-wall Carbon Nanotubes and Carbon Nanofibers: Toxicological Characterization in the Lungs 
Dale W. Porter—NIOSH

Vascular Consequences of Nanomaterial Exposure: From the Heart to the Fetus
Phoebe Stapleton—West Virginia Univ. Hlth. Sci. Ctr.

Evaluating the Safety Implications and Dermal Hazards Associated with Nanomaterials
Nancy A. Monteiro-Riviere—Kansas State Univ.

Student/Postdoc Best Abstract Competition

Westin Boston Waterfront
6:30 pm–8:30 pm

Board of Publications Trustees Joint Editorial Board Dinner

Westin Boston Waterfront
7:30 pm–11:00 pm
By Invitation only 

ASPET Student & Postdoc Mixer

Westin Boston Waterfront
8:30 pm–11:00 pm

Division for Behavioral Pharmacology Executive Committee Meeting

Westin Boston Waterfront
7:30 am–9:30 am

Division for Pharmacology Education Executive Committee Meeting

Westin Boston Waterfront
7:30 am–9:30 am

ASPET/BPS Pharmacology Research & Perspectives Meeting

Westin Boston Waterfront
7:30 am–9:30 am
By Invitation Only 

Molecular Pharmacology Editorial Board Meeting

Westin Boston Waterfront
7:30 am–9:30 am

Division for Neuropharmacology Executive Committee Meeting

Westin Boston Waterfront
7:30 am–9:30 am

John J. Abel Award in Pharmacology Lecture

Boston Convention Center
8:30 am–9:20 am
Speaker: Pieter Dorrestein—Univ. of California, San Diego
Creating the Facebook for Molecular Analysis 

New Therapies for an Old Problem: The NINDS-Sponsored Anticonvulsant Screening Program

Boston Convention Center
9:30 am–12:00 pm

Chairs:
John H. Kehne—Nat’l Inst. for Neurological Disorders and Stroke
Peter West—Univ. of Utah

Sponsored by the Divisions for: 

• Drug Discovery and Development 
• Neuropharmacology 
• Translational and Clinical Pharmacology 
• Molecular Pharmacology 

The NINDS Anticonvulsant Screening Program—Background and Overview
John H. Kehne, NINDS/NIH

Implementation of Novel Models to Address the Unmet Medical Needs in Epilepsy Treatment
Peter West, Univ. of Utah

Preclinical Evaluation of Cannabidiol in the Anticonvulsant Screening Program as a Potential Treatment for Epilepsy
Catherine Jacobson, Privateer Holdings, Inc. 

Development of Extended Neuroamides and the Role of the NINDS Anticonvulsant Screening Program
Harold L. Kohn, Univ. of North Carolina

A Medicinal Chemical Approach to Design of A1 Adenosine Receptor Agonists for Seizure Treatment
Kenneth A. Jacobson, NIDDK

Pharmacology of Neuronal Regeneration and Repair

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Jonathan S. Marchant—Univ. of Minnesota
Brock Grill—The Scripps Res. Inst.

Sponsored by the Divisions for: 

• Neuropharmacology 
• Molecular Pharmacology 
• Translational and Clinical Pharmacology 
• Drug Discovery and Development 

From Yeast to Patient Neurons and Back Again: Powerful New Discovery Platforms
Daniel Tardiff—Yumanity Therapeutics

The RPM-1/FSN-1 Ubiquitin Ligase Complex: Structure-Function Analysis Leads to a Peptide with Potential Implications for Neurodegeneration
Brock Grill—Scripps Res. Inst.

Imaging-Based Chemical Screening Reveals Activity-Dependent Neural Differentiation of Pluripotent Stem Cells   
Su Guo—Univ. of California, San Francisco

Pharmacological Biasing of Stem Cell Differentiation In Vivo: A Worm’s Eye View
Jonathan Marchant—Univ. Minnesota

Neural-Circuit Modulation of Stem-cell Function
Patricia Paez-Gonzalez—Duke Univ.

Membrane Transporters at the Interface of Drug Interactions, Biomarker Monitoring and Toxicity

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Lauren M. Aleksunes—Rutgers Univ.
Yurong Lai—Bristol-Myers Squibb Company

Sponsored by the Divisions for: 

• Toxicology 
• Drug Metabolism 
• Molecular Pharmacology 
• Cardiovascular Pharmacology 
• Translational and Clinical Pharmacology 
• Drug Discovery and Development 

Predicting Drug-Drug Interactions at Renal Organic Anion Transporters
Ryan Pelis—Dalhousie Univ.

Endogenous Probes for Evaluation of Drug-Drug Interactions Involving Renal Transporters
Hiroyuki Kusuhara—The Univ. of Tokyo

Alterations in Transporter Expression and Function in In Vitro and In Vivo Models of Kidney Disease
Melanie Joy—Univ. of Colorado

Bio-synthesis and Disposition of Bile Acids in Cultured Hepatocyte: In Vitro Predictive Models for Drug-Induced Liver Injury
Yurong Lai—Bristol-Myers Squibb Co.

Pharmacological Activation of Fxr Attenuates Pregnancy-Induced Repression of Hepatic and Ileal Bile Acid Transporters in Mice
Jamie E. Moscovitz—Rutgers Univ.

Protein Trafficking and Drug Development

Boston Convention Center
9:30 am–12:00 pm

Chair: P. Michael Conn—Texas Tech Univ. Hlth. Sci. Ctr.

Sponsored by the Divisions for: 

• Molecular Pharmacology 
• Translational and Clinical Pharmacology 
• Drug Discovery and Development 
• Toxicology 
• Neuropharmacology 

Rescue of GPCR Mutants In Vivo
P. Michael Conn—Texas Tech Univ. Hlth. Sci. Ctr.

Genetic Modification of Pituitary Gonadotropic Hormone Trafficking and Secretion
T. Rajendra Kumar—Kansas Univ. Med. Ctr.

Trafficking of Calcium Sensing Receptors as a Viable Target to Modulate Signaling
Gerda E. Breitwieser—Geisinger Clinic

The GGA Family Proteins Modulate the Cell Surface Transport of α2B-Adrenergic Receptor through Specific Interactions
Maoxiang Zhang —Georgia Regents Univ.

Psychomotor Stimulant Addiction: Lessons from Methamphetamine

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Rajeev I. Desai—McLean Hosp./Harvard Med. School
Michael A. Nader—Wake Forest Sch. of Med.

Sponsored by the Divisions for: 

• Behavioral Pharmacology 
• Neuropharmacology 

Drug History Alters Methamphetamine Effects at the Dopamine Transporter
Erin Calipari—Icahn Sch. of Med./Mount Sinai Sch. of Med.

Methamphetamine in Rodents and Primates: Physiology and Effects on Cognitive Performance
Michael A. Taffe—The Scripps Res. Inst.

Modification of Discriminative-Stimulus Effects of Dopaminergic Drugs During Chronic Methamphetamine Exposure
Jack Bergman—Harvard Med. Sch./McLean Hosp.

The Behavioral and Neuropharmacological Effects of Methamphetamine and Cocaine Self-Administration
Michael A. Nader—Wake Forest Sch. of Med.

Subjective, Reinforcing and Cognitive Effects of Methamphetamine in Humans
Richard De La Garza II—Baylor College of Medicine

Monoamines and Neurotrophins in Inflammatory Bowel Disease/Irritable Bowel Syndrome

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Hamid I. Akbarali—Virginia Commonwealth Univ.
Sandor Szabo—Univ. of California, Irvine/VA Med. Ctr.

Sponsored by the Divisions for: 

• Translational and Clinical Pharmacology 
• Toxicology 
• Molecular Pharmacology 

Serotonin Signaling in the Gastrointestinal Tract
Gary Mawe—Univ. of Vermont

Neurotrophin Signaling in the Gastrointestinal Tract
John R. Grider—Virginia Commonwealth Univ.

The Unexpected Role of Central & Peripheral Dopamine in the Pathogenesis of Gastrointestinal Ulceration
Sandor Szabo—Univ. of California, Irvine Sch. of Med.

The Role of Dopamine Receptors in Vascular Permeability & Angiogenesis in IBD
Ganna Tolstanova—Taras Shevchenko Nat. Univ. of Kiev

Pharmacological Reviews Editorial Board Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm
By Invitation Only 

ASPET Poster Presentations

Boston Convention & Exhibition Center
12:30 pm–2:30 pm

Division for Translational and Clinical Pharmacology Executive Committee Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Division for Molecular Pharmacology Executive Committee Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Mentoring & Career Development Committee Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Pharmacological Reviews Editorial Board Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Division for Toxicology Executive Committee Meeting

Westin Boston Waterfront
12:30 pm–2:30 pm

Division for Drug Metabolism Early Career Achievement Award Lecture

Boston Convention & Exhibition Center
2:00 pm–2:50 pm
Speaker: Namandjé N. Bumpus—The Johns Hopkins Univ. Sch. of Med.
Drug Metabolism Considerations in HIV Treatment and Prevention 

ASPET/BPS Pharmacology Research & Perspectives Management Committee Meeting

Westin Boston Waterfront
3:00 pm–5:00 pm
By Invitation Only 

ASPET Journal Symposium: Reproducibility in the Pharmacological Sciences: Moving the Discussion Forward

Boston Convention Center
3:00 pm–5:30 pm

Chair: Darrell R. Abernethy—Food and Drug Administration

Sponsored by the Divisions for: 

• Behavioral Pharmacology 
• Cardiovascular Pharmacology 
• Drug Discovery and Development 
• Drug Metabolism 
• Neuropharmacology 
• Translational and Clinical Pharmacology 
• Molecular Pharmacology 
• Pharmacology Education 
• Toxicology 

The Necessity of Publishing Replication and Failure to Replicate Studies: Criteria and Venues
Darrell R. Abernethy—FDA

Replication in Pharmacological Studies: What are the Specific Issues?
Michael Williams—Feinberg Sch. of Med.

Tracking Replicability: An Approach to Assess Reproducibility Following Publication
Adena Schachner—Boston Univ. 

The Urgent Need for Standards in Life Science Research
Leonard P. Freedman—Global Biological Standards Inst.

New Roles of Mitochondria in Vascular Function

Boston Convention Center
3:00 pm–5:30 pm

Chairs:
David W. Busija—Tulane Univ. Sch. of Med.
Prasad Katakam—Tulane Univ. Sch. of Med.

Sponsored by the Divisions for: 

• Cardiovascular Pharmacology 
• Molecular Pharmacology 
• Toxicology 

Mitochondrial Control of Ca2+ Signaling in Vascular Smooth Muscle
John G. McCarron—Univ. of Strathcyde

Resilient Mitochondrial Mechanisms in Endothelium Following Ischemia
David W. Busija—Tulane Univ. Sch. of Med.

Connecting Metabolism to Flow: The Role of Mitochondrial Generated Reactive Oxygen Species
William M. Chilian—Northeast Ohio Med. Univ.

Mechanisms of Control of Mitochondrial Structure and Function by Ovarian Hormones
Diana N. Krause—Univ. of California, Irvine

Sex-differences in Mitochondrial Respiration in Rat Cerebral Arteries
Ibolya Rutkai—Tulane Univ.

Curcumin-Encapsulated Stem Cell Exosomes Mitigates Neuro-Vascular Mitochondrial Dysfunction after Stroke in T1DM Mice
Anuradha Kalani—Univ. of Louisville

Division for Drug Discovery and Development Symposium: Drug Development in Academic Centers

Boston Convention Center
3:00 pm–5:30 pm

Chairs:
Robert J. Leadley, Jr.—Schoolcraft Coll.
Robert W. Caldwell—Georgia Regents Univ.

Anatomy of the 5-HT2C Receptor: Probing for Therapeutic Gain in Addictive Disorders
Kathryn A. Cunningham—Univ. of Texas Med. Branch-Galveston

Development of "Multifunctional" Compounds for the Treatment of Neuropsychiatric Disorders
Alvin V. Terry, Jr.—Georgia Regents Univ.

Developing Novel Therapeutics for Parkinson's Disease
Carrie K. Jones—Vanderbilt Univ. Med. Ctr.

Selective Antagonism of mGlu5 Alters Sleep-Wake and Spectral EEG and Ameliorates Behavioral Abnormalities in a Rodent Model of Traumatic Stress
Michael Nedelcovych—Vanderbilt Univ.

Ligand-Based Pharmacophore Modeling of 5-HT2A Receptor Biased Agonism
Kevin S. Murnane—Mercer Univ.

Allosteric Ligands of Metabotropic Glutamate Receptor 5 Have Biased Agonism and Cooperativity
Karen J. Gregory—Monash Inst. of Pharmaceutical Sciences

Division for Drug Metabolism James Gillette Award and Platform Session: Biotransformation and Drug Transport

Boston Convention Center
3:00 pm–5:30 pm

Chairs:
E.E. Scott—Univ. of Kansas
L.C. Wienkers—Amgen

Division for Molecular Pharmacology Postdoctoral Award Finalists

Boston Convention Center, Room 5B
3:00 pm–5:30 pm
Keynote Speaker: Jeffrey L. Benovic—Thomas Jefferson Univ.

Division for Neuropharmacology Postdoctoral Scientist Award Finalists

Boston Convention Center, Room 2
3:00 pm–5:30 pm
Keynote Speaker: Brigitte Kieffer—Douglas Research Ctr., McGill Univ.

Division for Drug Discovery and Development Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Drug Metabolism Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Molecular Pharmacology Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Neuropharmacology Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Pharmacology Education Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

ASPET Past Presidents’ Dinner

Westin Boston Waterfront
6:00 pm–9:00 pm
By Invitation Only 

Divisions for Behavioral Pharmacology and Neuropharmacology Joint Mixer

Westin Boston Waterfront
6:30 pm–8:00 pm

Divisions for Drug Discovery and Development; Translational and Clinical Pharmacology; and Pharmacology Education Joint Mixer

Westin Boston Waterfront
6:30 pm–8:00 pm

Division for Molecular Pharmacology Mixer

Westin Boston Waterfront
6:30 pm–8:00 pm

ASPET Networking Walk

Westin Boston Waterfront
7:00 am–9:00 am
Weather permitting 

Drug Metabolism and Disposition Editorial Board Meeting

Westin Boston Waterfront
7:30 am–9:30 am

Nominating Committee Meeting

Westin Boston Waterfront
7:30 am–9:30 am

Reynold Spector Award in Clinical Pharmacology Award Lecture

Boston Convention Center
8:30 am–9:20 am
Speaker:Scott A. Waldman—Thomas Jefferson Univ
Bench-to-Bedside Translation in Clinical Pharmacology: From Knowledge Generation to Healthcare Delivery 

The Human Microbiome: Systems Pharmacology Insights and the Potential for New Drug Discovery

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Ross Corriden—Univ. of California, San Diego Sch. of Med.
Christopher LaRock—Univ. of California, San Diego Sch. of Med.

Sponsored by the Divisions for: 

• Translational and Clinical Pharmacology 
• Molecular Pharmacology 
• Drug Discovery and Development 
• Cardiovascular Pharmacology 

The Human Microbiome in Health and Disease
Sarkis Mazmanian—Caltech

Inflammatory Cell Dynamics in Cancer and Infection: Interrogating the Role of the Microbiome
Amiran Dzutsev—NCI

Pharmacomicrobiomics: The Impact of Human Microbiome Variations on Systems Pharmacology and Personalized Therapeutics
Ramy K. Aziz—Cairo Univ.

Obesity and Gut Barrier Function: Using the Microbiota and Prebiotics to Understand Early Consequences of a High Fat Diet
Kristi Hamilton—Univ. of California, Davis

Novel Therapeutic Targets and Preclinical Models of Post-traumatic Stress Disorder

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Carrie K. Jones—Vanderbilt Univ. Med. Ctr.
Michael Nedelcovych—Vanderbilt Univ. Med. Ctr.

Sponsored by the Divisions for: 

• Behavioral Pharmacology 
• Neuropharmacology 
• Toxicology 

PTSD and the Neurocircuitry of Impaired Fear Extinction
Mohammed Milad—Harvard Med. Sch., Mass Gen. Hosp.

Using Positron Emission Tomography (PET) to Gain Insight into Targeted Pharmacological Treatment of PTSD
Alexander Neumeister—NY Univ. Langone Med. Ctr.

Sleep-wake Disturbances as a Predictor of PTSD Susceptibility: Implications for Early Intervention after Traumatic Stress
Thomas Mellman—Howard Univ. Coll. Med.

Sleep/Wake and Quantitative Electroencephalography (EEG) Disruptions in a Rodent Model of PTSD: Potential Preclinical Biomarkers for Drug Effects
Michael Nedelcovych—Vanderbilt Univ. Med. Sch.

Challenges of Implementing Basic Preclinical Methods to Identify Candidate Compounds Toward the Advancement of New Pharmacological Therapies for PTSD and Related Disorders
Raymond F. Genovese—Walter Reed Army Inst. of Res.

New Technologies to Measure Mitochondrial Changes

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Craig C. Beeson—Medical Univ. of South Carolina
Brian S. Cummings—Univ. of Georgia

Sponsored by the Divisions for: 

• Toxicology  
• Drug Metabolism 

Identification of Mitochondrial Toxicophores
Craig C. Beeson—Med. Univ. of South Carolina

Identification of Mitochondrial Toxicants and Mitochondrial Changes in Human Tissues
Dean P. Jones—Emory Univ.

Urinary Biomarkers of Mitochondrial Dysfunction
Rick G. Schnellmann—Med. Univ. of South Carolina

Mitochondrial Subpopulation Lipidomics in Aging Tissue
Brian S. Cummings—Univ. of Georgia

Idiosyncratic Drug-Induced Liver Injury Potential of Zileuton is Detected in Diversity Outbred Mice
Alison H. Harrill—Univ. of Arkansas for Med. Sciences

Pesticide-Induced Mitochondrial Dysfuntion Augments NLRP3 Inflammasome Signaling Pathway in Primary Microglia
Souvarish Sarkar—Iowa State Univ.

Systems Pharmacology: Enhancing Translational Research by Network and Pharmacodynamic Modeling

Sponsored by: Merck
Boston Convention Center
9:30 am–12:00 pm

Chairs:
Donald E. Mager—Univ. at Buffalo, SUNY
Darrell R. Abernethy—Food and Drug Adminstration

Sponsored by the Divisions for: 

• Divisions for Drug Discovery and Development 
• Translational and Clinical Pharmacology  
• Toxicology 

Systems Pharmacology for Prediction of Adverse Drug Events
Darrell R. Abernethy—OTS/CDER/FDA

Network Analysis to Identify Multiscale Mechanisms of Drug Action
Douglas A. Lauffenburger—MIT

Merging Network Analysis and Pharmacodynamics for Translational Modeling
Donald E. Mager—Univ. at Buffalo, SUNY

Computational and Functional Genomics to Understand Human Disease and Drug Response
Nadav Ahituv—Univ. of California, San Francisco

Extraction and Integration of Diverse Data Streams to Support Systems Networks
Nigam Shah—Stanford Univ.

Biased GPCR Signaling in Drug Development: From Theory to Physiology

Sponsored by: DiscoveRX and Merck
Boston Convention Center
9:30 am–12:00 pm

Chairs:
Sudarshan Rajagopal—Duke Univ. Med. Ctr.
Patrick Sexton—Monash Univ.

Sponsored by the Divisions for: 

• Molecular Pharmacology 
• Neuropharmacology 
• Drug Discovery and Development 
• Translational and Clinical Pharmacology  

Biased Receptor Signaling and Beyond
Terry Kenakin—Univ. of North Carolina Sch. Of Med.

Structural Features Responsible for GPCR Functional Selectivity
Bryan Roth—Univ. of North Carolina

Delineating the Dynamics of Mu-opioid Receptor Signaling and Regulation
Meritxell Canals—Monash Univ.

Implications for GPCR Functional Selectivity/Biased Signaling in the Actions of Dopamine
Marc Caron—Duke Univ. Med. Ctr.

Bias in The 4th Dimension: The Influence of Ligand Binding Kinetics Upon The Quantification of Biased Agonism at G Protein-Coupled Receptors
J. Robert D. Lane —Monash Inst. of Pharmaceutical Sciences

A Pre-Assembled GPCR-Signalosome Reveals Unappreciated Ligand Sensitivity and Mediates Unique Whole Cell Responses
Michelle L. Halls —Monash Inst. of Pharmaceutical Sciences

Cardiac Fibroblasts: Fair-weather Friends in Myocardial Fibrosis and Repair

Sponsored by: Bristol-Myers Squibb
Boston Convention Center
9:30 am–12:00 pm

Chairs:
Paul Insel—Univ. of California, San Diego Sch. of Med.
Ulrike Mende—Rhode Island Hospital & Alpert Med. Sch. of Brown Univ.

Sponsored by the Divisions for: 

• Cardiovascular Pharmacology 
• Molecular Pharmacology 
• Drug Discovery and Development 

New Ideas on Cardiac Fibroblast Activation and New Therapeutic Approaches
Boris Hinz—Univ. of Toronto

Cardiac Fibroblasts and Cellular Cross Talk in Heart Failure
Burns C. Blaxall—Univ. of Cincinnati/Cincinnati Children's Hosp.

GPCRs as Regulators of Cardiac Fibroblasts
Paul Insel—Univ. of California, San Diego

Extracellular Matrix-Cardiac Fibroblast Communication: New Opportunities for Therapy
Merry L. Lindsey—Univ. of Mississippi Med. Ctr.

Eicosapentaenoic Acid Prevents Interstitial Cardiac Fibrosis in a Mouse Model of Hypertensive Heart Disease
Julie A Eclov —Univ. of South Dakota

Persistent Phenotypic Shift in Cardiac Fibroblasts Following Transient ACE Inhibition
Lakshmi Madhavpeddi—Univ. of Arizona

“Can We Talk?” Strategies for Collaborative Pharmacology Education

Boston Convention Center
9:30 am–12:00 pm

Chairs:
A. Laurel Gorman—Univ. of Central Florida Coll. of Med
Jayne S. Reuben—Univ. of South Carolina-Greenville Sch. of Med.
John L. Szarek—Commonwealth Med. Coll.

Sponsored by the Divisions for: 

• Pharmacology Education 
• Molecular Pharmacology 
• Cardiovascular Pharmacology  
• Neuropharmacology 

Simulations as a Tool to Enhance Collaborative Pharmacology Learning in the Context of Professionalism, Interprofessional Communication, and Teamwork
John L. Szarek—Commonwealth Med. Coll.

Using Small Group Case Studies to Teach Pharmacotherapeutics for a Diverse World
Jayne S. Reuben and Peggy Wagner—Univ. of South Carolina-Greenville Sch. of Med.

Many Heads are Better Than One: It's TBL time
A. Laurel Gorman—Univ. of Central Florida Coll. of Med

ASPET Poster Presentations

Boston Convention & Exhibition Center
12:30 pm–2:30 pm

Division for Translational and Clinical Pharmacology:
Meet The Experts Lunch: Benchside-to-Bedside Research

Westin Boston Waterfront
12:30 pm–2:30 pm
This session is full.
Chair: Michael Holinstat—Thomas Jefferson Univ.

Division for Cardiovascular Pharmacology Trainee Showcase

Boston Convention Center
2:30 pm–4:30 pm
Chairs:
L.E. See Hoe—Griffith Univ.
J.M. Schilling—Univ. of California, San Diego 

Presynaptic Autoreceptors and Improved Treatments of Major Psychiatric Disorders

Boston Convention Center
3:00 pm–5:30 pm

Chair: Salomon Z. Langer—Euthymia, Ltd.

Sponsored by the Divisions for: 

• Neuropharmacology 
• Molecular Pharmacology 
• Behavioral Pharmacology 
• Drug Discovery and Development 
• Translational and Clinical Pharmacology 

Presynaptic, Autoreceptor-Mediated Regulation of Neurotransmission: Physiological and Pharmacological Relevance
Salomon Z. Langer—Euthymia, Ltd.

Mechanism of Action of Alpha-2 Adrenoceptor Agonists in ADHD and Related Prefrontal Cortical Disorders
Amy Arnsten—Dept. of Neurobiology, Yale Univ. Sch. of Med.

Implicating the Alpha-2 Receptor in Unique Actions of Drugs
William Z. Potter—NIMH

Role of Monoaminergic Autoreceptor Desensitization in the Antidepressant Response
Pierre Blier—University of Ottawa, Canada

Structural and Dynamic Basis of Receptor-ligand Interactions

Boston Convention Center
3:00 pm–5:30 pm

Chairs:
Eric Ortlund—Emory Univ. Sch. of Med.
Stephen F. Traynelis—Emory Univ.

Sponsored by the Divisions for: 

• Molecular Pharmacology  
• Neuropharmacology 
• Translational and Clinical Pharmacology 

Structural Advances in Glutamate Receptors
Hiro Furukawa— Cold Spring Harbor Laboratory

Structural Studies of Allostery at the M4 Muscarinic Acetylcholine Receptor
David M Thal— Monash Institute of Pharmaceutical Sciences

Cryo-Electron Microscopy Comes of Age: Applications to Molecular Pharmacology
Sriram Subramaniam— National Cancer Institute / NIH

Differential Hydrogen/Deuterium Exchange Mass Spectrometry to Study Receptor-Ligand Signaling
Patrick Griffin— The Scripps Research Inst., Florida

Unexpected Allosteric Network Drives Nuclear Receptor-Phospholipid Signaling
Eric A Ortlund— Emory University School of Medicine

Division for Behavioral Pharmacology Symposium: Sigma Receptors in Health and Disease

Boston Convention Center
3:00 pm–5:30 pm

Chair: Habibeh Khoshbouei—Univ. of Florida

Sigma1 in Cancer Cell Protein Homeostasis
Kim J. Felix—Drexel Univ. Coll. of Med.

Sigma-1R-Dependent Modulation of Neuronal Excitability: A Novel Mechanism Involved in Addictive Processes
Said Kourrich—Univ. of Texas Southwest. Med. Ctr.

Sigma Receptor Involvement in Stimulant Abuse
Jonathan Katz—NIDA-IRP

A Role for Sigma Receptors in Excessive Alcohol Drinking
Valentina Sabino—Boston Univ. Sch. of Med.

Sigma-1R Regulation of Dopamine Transporter
Habibeh Khoshbouei—Univ. of Florida

Division for Translational and Clinical Pharmacology: Young Investigator Awards Platform Session

Boston Convention Center
3:00 pm–5:30 pm
Chairs: To be decided

Division for Toxicology Symposium: Pharmacogenetics and Drug Toxicity

Boston Convention Center
3:00 pm–5:30 pm
Chair: Gary O. Rankin—Marshall Univ.

Warfarin Pharmacogenetics: Trials and Tribulations
Brian F. Gage—Washington Univ. Sch. of Med. in St. Louis

CYP2D6 Pharmacogenetics: Controlling the Atomoxetine Dose-Exposure Relationship to Improve Efficacy and Reduce Toxicity in Adolescents with ADHD
J. Steven Leeder—Children’s Mercy Kansas City

Carboxylesterase 1: Recent Developments in Pharmacogenetics
John S. Markowitz—Univ. of Florida

Role of Genetic Polymorphisms in Metabolism and Toxicity of Drugs of Abuse
Lauren Richard-Waugh—Marshall Univ.

Benedict R. Lucchesi Distinguished Lectureship in Cardiac Pharmacology

Boston Convention Center
4:30 pm–5:30 pm
Speaker: Andre Terzic—Mayo Clinic
Regenerative Therapy for the Failing Heart 

Division for Behavioral Pharmacology Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Cardiovascular Pharmacology Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Translational and Clinical Pharmacology Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Toxicology Annual Meeting

Boston Convention Center
5:30 pm–6:30 pm

Division for Cardiovascular Pharmacology Mixer

Westin Boston Waterfront
6:30 pm–8:00 pm

Divisions for Drug Metabolism and Toxicology Joint Mixer

Westin Boston Waterfront
6:30 pm–8:00 pm

2015 Catecholamine Society Dinner and Lecture

Scampo, 215 Charles Street, Boston
Pre-dinner reception starts at 6:30 pm followed by dinner.
Event Flyer 

Norman Weiner Lecture

Boston Convention Center
8:30 am–9:20 am
Speaker: William A. Catterall—Univ. of Washington
Structural Basis for Function and Pharmacology of Voltage-Gated Sodium and Calcium Channels  

Structural Basis for Ion Channel Pharmacology

Boston Convention Center
9:30 am–12:00 pm

Chair: William A. Catterall—Univ. of Washington

Sponsored by the Divisions for: 

• Molecular Pharmacology 
• Neuropharmacology 
• Translational and Clinical Pharmacology 

Structure and Mechanism of Pentameric Neurotransmitter Receptors
Ryan Hibbs—Univ. of Texas Southwestern Medical Center 

Mechanism of Drug and Agonist Action on Glutamate Receptors
Stephen Traynelis—Emory Univ. Sch. Of Med.

Structural Basis for G Protein Regulation of Kir Channels
Matt Whorton—Vollu Inst., Oregon Health & Science Univ.

Structural Basis for Pharmacology of TRPV1 Channels
Erhu Cao—Univ. of California, San Francisco

Common Pathways and Mechanisms of Chronic Pain and Opioid Addiction

Boston Convention Center
9:30 am–12:00 pm

Chair: Susan L. Ingram—Oregon Hlth. and Sci. Univ.

Sponsored by the Divisions for: 

• Neuropharmacology 
• Behavioral Pharmacology 
• Molecular Pharmacology  
• Translational and Clinical Pharmacology 
• Drug Discovery and Development 

NIH Efforts to Reduce Prescription Opioid Abuse and Improve Pain Treatment
David Thomas—NIDA/NIH

Neuropathic Pain Modulates Dopaminergic Circuitry: Role for Microglial Activation
Catherine Cahill—Univ. of California, Irvine

Role of Ventral Tegmental Area TORC2 Signaling in Stress-Induced Morphine Reward
Sophie Kaska—Michigan State Univ.

Chronic Pain Increases Opioid Self-Administration through an Accumbal Dopaminergic Mechanism
Jose Moron-Concepcion—Columbia Univ. Med. Ctr.

Extrasynaptic GABAA Receptors in the Periaqueductal Gray are Involved in Descending Pain Modulation and Chronic Inflammatory Pain-Induced Plasticity
Susan L. Ingram—Oregon Hlth. & Sci. Univ.

Effects of Daily Morphine treatment on Impulsivity in Rats Responding Under a 5=Choice Serial Reaction Time Task
David McGuire—Univ. of Texas Health Science Ctr., San Antonio

Moving Beyond Traditional Stimulants: Emerging Characteristics and Therapeutic Applications of Atypical Reuptake Inhibitors

Sponsored by: Jazz Pharmaceuticals
Boston Convention Center
9:30 am–12:00 pm

Chairs: 
Lawrence P. Carter—Jazz Pharmaceuticals, Inc.
Bruce E. Blough—Research Triangle Inst.

Sponsored by the Divisions for: 

• Behavioral Pharmacology 
• Molecular Pharmacology 
• Neuropharmacology 
• Translational and Clinical Pharmacology 

Is Modafinil an Atypical DAT Inhibitor?
Michael Baumann—NIDA/NIH

Molecular Approaches for Differentiating Atypical Uptake Inhibitors from Traditional Stimulants at the Dopamine Transporter
Maarten Reith—New York Univ. Sch. Of Med.

Chemical and Pharmacological Approaches for Differentiating Atypical Monoamine Releasers and Uptake Inhibitors from Traditional Stimulants
Bruce Blough—Research Triangle Inst.

Clinical and Pharmacological Relevance of Rebound Hypersomnia in Differentiating Traditional Stimulants from Wake Promoting Agents
Mehdi Tafti—Univ. de Lausanne

Characterization of the Atypical Effects of JZP-110 at the Dopamine Transporter and in Clinical Trials
Lawrence Carter—Jazz Pharmaceuticals

Natural Products: Bioactive Molecules from Nature

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Benedict T. Green—ARS/USDA
Bruce E. Blough—Research Triangle Inst.

Sponsored by the Divisions for: 

• Translational and Clinical Pharmacology 
• Toxicology 
• Drug Metabolism 

Marine Toxins in Nicotinic Receptor Targeted Drug Design
William R. Kem—Univ. of Florida

The "Fungal Pharmacy": A Source for Structurally Diverse and Bioactive Compounds
Nicholas H. Oberlies—Univ. of North Carolina at Greensboro

CNS Drug Discovery from Marine Cyanobacteria
Kevin J. Tidgewell—Duquesne Univ.

Toxicities and Teratogenic Potential of Piperidine and Pyridine Enantiomers from Plants
Steven T. Lee—ARS/USDA

Targeting Lactate Effux Inhibition for the Development of Potent Antiproliferative Agents
Samia S. Messeha—Florida A&M Univ

Characterization of Synthetic Ircinianin Analogues as Potent and Selective Modulators of A3 Glycine Receptor
Sahil Talwar—Univ. of Queensland

Crossing the Line: Exploring the Borders Between Physiological Redox Signaling and Oxidative Stress

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Thomas Michel—Brigham and Women’s Hosp./Harvard Med. Sch.
Marcia Haigis—Harvard Med. Sch.

Sponsored by the Divisions for: 

• Cardiovascular Pharmacology 
• Toxicology 
• Molecular Pharmacology 
• Drug Discovery and Development 
• Translational and Clinical Pharmacology 

Hydrogen Peroxide in Cardiovascular Signal Transduction
Thomas Michel—Brigham and Women’s Hosp.

Mitochondria as Signaling Organelles
Navdeep Chandel—Northwestern Univ.

Posttranslational Regulation of Nox4 and its Role in Heart Failure
Junichi Sadoshima—Rutgers New Jersey Med. Sch.

Dynamic Regulation of the Nitrosothiol Proteome in Cardiovascular Disease
Elizabeth Murphy—NIH/NHLBI

Oxidative Metabolism, Oxidative Stress, and Aging: New Insights into the Roles of Sirtuins
Marcia Haigis—Harvard Med. Sch.

FP Prostanoid Receptor Mediated Up-Regulation of Hypoxia-Inducible Factor-1a Through Activation of Mitogen-Activated Protein Kinase and Reactive Oxygen Species Signaling Pathways
Christopher Sanchez—Univ. of Arizona

Transporter-mediated Drug Interactions: Clinical Significance and Predictions

Boston Convention Center
9:30 am–12:00 pm

Chairs:
Maciej J. Zamek-Gliszcznski—GlaxoSmithKline
Caroline Lee—QPS, LLC.

Sponsored by the Divisions for: 

• Drug Metabolism 
• Toxicology 
• Cardiovascular Pharmacology 

Can We Prospectively Predict Complex DDIs Involving Hepatic OATPs?
Aleksandra Galetin—Manchester Pharmacy School

Prediction of Digoxin Clinical Drug-Drug Interactions from In Vitro Transporter Assays
Caroline A. Lee—Ardea Biosciences

Is BCRP Relevant to Clinical Drug PK, and What are the Best Practices in BCRP DDI Study Design?
Joseph W. Polli—GlaxoSmithKline

When are Renal Transport DDIs Relevant from a PK and Kidney Toxicity Perspective?
Joanne Wang—Univ. of Washington

Why Have Clinical DDIs Not Been Observed at the Level of BBB Efflux?
Maciej J. Zamek-Gliszczynski—GlaxoSmithKline

ASPET Poster Presentations

Boston Convention & Exhibition Center
12:30 pm–2:30 pm

ASPET accepts sponsorships funds from external organizations only if acceptance does not pose a conflict of interest and in no way impacts the objectivity of the society, its members, activities, programs, or employees. The ASPET scientific and educational program at the ASPET Annual Meeting is developed prior to, and independent of, educational grant support or commercial sponsorships. The commercial supporters of this meeting have no influence over topics or speakers.