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May, 2008
ASPET Government and Public Affairs Report Appropriations Update

A House bill that would have increased the set-aside for the Small Business Innovation Research (SBIR) from 2.5% to 3.0% of the research budget of each agency failed. However, Rep. Vern Ehlers’ (R-MI) amendment, supported by the AAU, AAMC and FASEB, stripped the increase from a committee reauthorization bill. Had the provision not been removed by amendment, passage of the set-aside increase would have essentially cut funding for other research programs at all agencies by $650 million.

There is also a supplemental spending bill being negotiated that is, not surprisingly, grinding forward with debates over priorities and war spending. There is potential for increased funding for biomedical research in the supplemental bill, but that might be difficult to realize. Nonetheless, a push has been made to Congressional leaders and appropriators to consider additional funds for NIH. There will be no progress on the actual FY 2009 Appropriations bills (exception is the Defense bill) until the Supplemental is completed.

ASPET Letter Supports Passage of Genetic Information Nondiscrimination Act
The Senate finally passed the Genetic Information Nondiscrimination Act (GINA) by a vote of 95-0. The House also approved the bill 414-1. The President is expected to sign the bill. GINA prohibits health insurance companies from using genetic information to deny benefits and raise premiums for individual policies, and makes it illegal for employers to use genetic information to make decisions about hiring, firing or compensation. One of the obstacles for the translation of pharmacogenetics to clinical practice is the risk for the misuse of genetic information in health insurance and employment decisions. Passage of GINA will “help researchers and clinicians to actively encourage Americans to participate in clinical trials without the fear of genetic discrimination,” said Joann Boughman, Ph.D,, executive vice president of the American Society of Human Genetics. Read ASPET’s letter of support for passage of the legislation: http://www.aspet.org/public/public_affairs/pa_pos_test.html

Global Alliance for Pharmacogenomics
NIGMS and two other NIH institutes recently signed a letter of intent with the Center for Genomic Medicine in Japan to create a Global Alliance for Pharmacogenomics. The alliance will identify genetic factors that contribute to individual responses to medicines, with the eventual goal of helping doctors optimize the safety and effectiveness of drugs for each patient. A news release on the alliance is at: http://www.nigms.nih.gov/News/Results/GAP-JAPAN04142008.htm

NIDA Director Testimony on the Pharmacology of Addiction
NIDA Director Nora Volkow testified in front of the U.S. Senate Judiciary Committee’s Subcommittee on Crime and Drugs regarding the scope, pharmacology, and health consequences of cocaine abuse and addiction. http://www.nida.nih.gov/Testimony/2-12-08Testimony.html

Great Ape Protection Act
The Great Ape Protection Act (HR 5852) was introduced by Rep. Towns (D-NY) would potentially prohibit the conduct of invasive research on chimpanzees, gorillas, and other non-human primates. The bill could affect the ability of researchers to perform non-invasive behavioral research since it would prevent even blood draws. Additionally, it would mandate federally-supported, permanent retirement for all great apes currently used in federally-funded research. The bill’s prospects are relatively remote at this stage. But passage would have an important effect on research and public health. ASPET is working with a broad coalition of interested organizations to monitor this legislation.

Training Opportunity: NIGMS Summer Short Courses in Integrative & Organ Systems Pharmacology
The National Institute of General Medical Sciences will once again fund four summer short courses that provide specialized training for using intact organ system and in vivo animal models in the conduct of research. The purpose of each short course is to introduce graduate students, post-docs and Ph.Ds to the knowledge and skills needed for integrative studies of organ systems and intact animals, and the physiological and biochemical responses of these systems to drugs. These critical skills are in short supply. Graduate students and Ph.Ds. with these skills are in great demand in both academic and industrial settings. Summer Short Courses in Integrative and Organ Systems Science are available at Michigan State University, University of California at San Diego, University of Nebraska Medical Center, and the University of North Carolina at Chapel Hill. Please view: http://www.aspet.org/public/public_affairs/pa_NIGMS_shortcourse_awards.html.  NIGMS is planning to continue the summer short courses from 2009 -2012.

ASPET-IOSS Fund Application Guidelines
The ASPET-IOSS Fund was created to provide support for graduate students and post-doctoral researchers seeking training in integrative whole organ systems sciences. The fund is currently supported by Abbott Laboratories, Merck Research Laboratories, Pfizer and Wyeth Research. The goal is to help augment developing programs (see above) that provide training of students in this field. For application, information, visit: http://www.aspet.org/public/public_affairs/pa_ioss.html

FASEB NEWS
For FASEB biweekly news from Capitol Hill: http://opa.faseb.org/.  Also available are links to the FASEB FY2009 Funding Recommendations for Science Agencies and information about FASEB’s new voter education initiative, ScienceCures.

Funding Opportunities

Toxicological Evaluation of Potential Medications to Treat Drug Addiction http://grants.nih.gov/grants/guide/notice-files/NOT-DA-08-025.html

Pharmacologic Agents and Drugs for Mental Disorders  http://grants.nih.gov/grants/guide/pa-files/PA-08-142.html


April 2008
ASPET Government and Public Affairs Report Appropriations Update


179 House members signed a March 19 letter to the House Appropriations Committee leadership requesting a 6.5% increase for the FY’09 NIH budget. The letter, sent to Reps. David Obey (D-WI) and Jerry Lewis (R-CA), chair and ranking member, respectively of the House Appropriations Committee, notes the Administration's proposal to fund NIH at the current level "is deeply troubling given the high rate of biomedical inflation.” Read ASPET’s written testimony to the House Labor/HHS Appropriations Subcommittee supporting a 6.5% increase: http://www.aspet.org/public/public_affairs/pa_pos_test.html

NIH Seeks Input on Current Needs in Pharmacogenomics Research
NIH invites responses from the scientific community, scientific organizations, pharmaceutical companies, Federal Agencies, and other interested parties well-versed in the areas of pharmacogenetics and pharmacogenomics, to help identify crucial needs, gaps and roadblocks to PGx research. NIH wants to identify ways in which the agency can effectively and efficiently address these barriers. Response due by April 30. View details at: http://grants1.nih.gov/grants/guide/notice-files/NOT-GM-08-125.html

ACTION ALERT
Legislative Action Needed to Pass Genetic Information Nondiscrimination Act
A major obstacle for the translation of Pharmacogenetics to clinical practice is the well-recognized risk for the misuse of genetic information for the purposes of making health insurance and/or employment decisions. Although there has been widespread legislative support for Genetic Nondiscrimination Act (GINA) in the House, it has yet to be passed by the Senate. Given the importance this issue has for an important advancement for Pharmacology, all ASPET members are encouraged to contact their Senators urging them to vote on passage of the bill. Action in the Senate has been delayed by the objections of one Senator (Coburn, R-OK). The only chance for passing the bill in the Senate is to bring the bill to a floor vote through a procedural mechanism in the next week or so. Senator Reid (D-NV), the Senate Majority Leader can bring the bill to the floor, but will do so only if he hears about GINA from different constituencies. ASPET members in Nevada are urged to contact Senator Reid’s office (tel: 202-224-3542) and ask that he bring the Genetic Nondiscrimination Act (S.358) to the Senate Floor. All other ASPET members should contact their respective Senate offices this week. Ask your Senator(s) to contact Senator Reid’s office to encourage him (Sen.Reid) to bring the Genetic Information Nondiscrimination Act to the floor. Your Senator’s phone numbers can be found at: http://geneticfairness.org/senator_list.html.  Background information on this issue can be viewed at: http://www.geneticfairness.org/.

ACTION ALERT
ASPET Florida Members Needed to Defend Teaching of Evolution

There are currently two bills in the Florida House and Senate that threaten the science curriculum in Florida’s public schools. Both bills are entitled the "Academic Freedom Act." The bills, if passed, would provide cover for the teaching of religious beliefs as science in Florida's science classrooms. The bills would authorize the "right to present scientific information relevant to the full range of views on biological and chemical origins. Prohibit a teacher from being discriminated against for presenting such information. Prohibit students from being penalized for subscribing to a particular position on evolution, etc." Creationists are working under the guise of "academic freedom" to legally authorize the teaching of inherently unscientific doctrine in science classes. If passed, Teachers or administrators could use these bills to defend the presentation of oft-refuted creationist attacks on evolutionary sciences. The bills authorize the teaching of a "full range of views on biological and chemical evolution," that would allow for creationist and intelligent design ideology at the expense of rigorously peer-reviewed material. Both bills also claim to protect teachers and students from discrimination for their beliefs, suggesting that discrimination exists where it does not, and to draw attention away from the subject matter of creationism. ASPET members in Florida are urged to contact their Legislators to convey your strong support for science in Florida classrooms and opposition to SB2692 and HB1483.  To find your legislator, view: [House] http://www.myfloridahouse.gov/SECTIONS/Representatives/representatives.aspx and [Senate] http://www.flsenate.gov/Legislators/index.cfm?Mode=Member Pages&Submenu=1&Tab=legislators&CFID=78606717&CFTOKEN=34571278.  Whether you call or write, state that you are opposed to the Academic Freedom Act (Senate Bill 2692 / House Bill 1483). If passed, this Act would provide cover for teaching religious beliefs as science in Florida public schools and, in doing so, impair students’ critical thinking skills, their ability to differentiate scientific from non-scientific information, their success in the 21st century workplace; impact our state's economy that increasingly rests on scientific industry and on the cultivation of scientific knowledge in our classrooms. Although scientists continue to question certain aspects of evolutionary science and conduct research to explore its ramifications, the core elements of evolution as presented in textbooks today have been repeatedly tested and verified. Good science education includes teaching evolution – it is not a matter of “academic freedom.” Students should be tested on their knowledge of these well-understood concepts, as embodied in the recently-passed state science standards, and legislators should insist that students spend their valuable classroom time learning, through classwork and homework, the best knowledge that centuries of scientific investigation have placed before them.

Farm Bill and Class B Dealers for Research
The Farm Bill appears to be moving forward. This may present the final opportunity to remove language prohibiting the use of non-purpose bred animals from Class B dealers for research. We have been informed that the offices of Senators Harkin (D-IA), Leahy (D-VT), and Stabenow (D-MI) may be crucial in assuring this provision does not move forward. FASEB has set up an legislative alert on the FASEB Capwiz site for members from Iowa, Vermont, and Michigan to take action: http://capwiz.com/faseb/issues/alert/?alertid=11261751&type=CO

Training Opportunity: NIGMS Summer Short Courses in Integrative & Organ Systems Pharmacology
The National Institute of General Medical Sciences will once again fund four summer short courses that provide specialized training for using intact organ system and in vivo animal models in the conduct of research. The purpose of each short course is to introduce graduate students, post-docs and Ph.Ds to the knowledge and skills needed for integrative studies of organ systems and intact animals, and the physiological and biochemical responses of these systems to drugs. These critical skills are in short supply. Graduate students and Ph.Ds. with these skills are in great demand in both academic and industrial settings. Summer Short Courses in Integrative and Organ Systems Science are available at Michigan State University, University of California at San Diego, University of Nebraska Medical Center, and the University of North Carolina at Chapel Hill. Please view: http://www.aspet.org/public/public_affairs/pa_NIGMS_shortcourse_awards.html.  NIGMS is planning to continue the summer short courses from 2009 -2012.

ASPET-IOSS Fund Application Guidelines
The ASPET-IOSS Fund was created to provide support for graduate students and post-doctoral researchers seeking training in integrative whole organ systems sciences. The fund is currently supported by Abbott Laboratories, Merck Research Laboratories, Pfizer and Wyeth Research. The goal is to help augment developing programs (see above) that provide training of students in this field. For application, information, visit: http://www.aspet.org/public/public_affairs/pa_ioss.html

Schedule of National Animal Welfare Education Programs. Workshops and Conferences
View: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-08-043.html

FASEB NEWS
For FASEB biweekly news from Capitol Hill: http://opa.faseb.org/
Also available are links to the FASEB FY2009 Funding Recommendations for Science Agencies and the launch of FASEB’s new voter education initiative, ScienceCures.

Howard Hughes Medical Institute (HHMI) New Award for Early Career Faculty.
The award is aimed at researchers who have run their own labs for two to six years and are at a critical point in establishing their own independent research programs. HHMI plans to select as many as 70 early career scientists from a wide range of scientific disciplines relevant to biological and medical inquiry. Scientists will receive six-year, non-renewable appointments to HHMI and substantial research support necessary to move their research in creative, new directions. HHMI will invest more than $300 million in this first group of scientists and plans a second competition in 2011. Visit: http://www.hhmi.org/research/competitions/earlycareer2009/

Funding Opportunities

Toxicological Evaluation of Potential Medications to Treat Drug Addiction http://grants.nih.gov/grants/guide/notice-files/NOT-DA-08-025.html

Pharmacologic Agents and Drugs for Mental Disorders http://grants.nih.gov/grants/guide/pa-files/PA-08-142.html 


March 2008
ASPET Government and Public Affairs Report Appropriations Update

The President’s FY’09 budget was released last month. The request for NIH is $29.2 billion which is equal to the FY’08 appropriation. The biomedical research community is advocating for an increase in the NIH by $1.9 billion in FY’09. The President’s proposed budget is the 6th consecutive year that the NIH does not keep pace with inflation. If the President’s FY’09 budget were to become law it would amount to NIH losing nearly 14% of its purchasing power to inflation over the past six years. FASEB, the National Health Council, The Ad Hoc Group for Medical Research, the Campaign for Medical Research, and Research!America have issued a joint statement urging Congress to accelerate medical progress by increasing investment in the NIH:http://www.aspet.org/public/public_affairs/pa_pos_test.html

The President’s budget proposal for FDA is $2.4 billion. This includes an appropriation of $1.77 billion and $628 million in user fees (a 3.1% and 14.4% increase, respectively) over the FY’08 level. The Alliance for a Stronger FDA is advocating for a $2.1 billion FY’09 appropriation, approximately a $380 million increase above the president’s level, not including user fees. For additional information on FDA funding visit: <www.StrengthenFDA.org> The Bush budget is dead on arrival. But even lame-duck presidents can still veto appropriations bills. President Bush will continue to do so until he leaves office in January 2009 and he will almost certainly veto any spending bill that is over his requested spending level. Once again, the likelihood of greater than inflation adjusted budgets is remote. It is possible a new president could enact an increase in some discretionary spending accounts upon taking office next January if the FY’09 budget is still not resolved. The new fiscal year begins October 1 but there will almost certainly be another in a series of continuing resolutions passed to keep government agencies operating well past October 1.

Training Opportunity: NIGMS Summer Short Courses in Integrative & Organ Systems Pharmacology
The National Institute of General Medical Sciences will once again fund four summer short courses that provide specialized training for using intact organ system and in vivo animal models in the conduct of research. The purpose of each short course is to introduce graduate students and Ph.Ds to the knowledge and skills needed for integrative studies of organ systems and intact animals, and the physiological and biochemical responses of these systems to drugs. These critical skills are in short supply. Graduate students and Ph.Ds. with these skills are in great demand in both academic and industrial settings. Summer Short Courses in Integrative and Organ Systems Science are available at Michigan State University, University of California at San Diego, University of Nebraska Medical Center, and the University of North Carolina at Chapel Hill. Please view: http://www.aspet.org/public/public_affairs/pa_NIGMS_shortcourse_awards.html.  NIGMS is planning to continue the summer short courses from 2009 -2012.

ASPET-IOSS Fund Application Guidelines
The ASPET-IOSS Fund was created to provide support for graduate students and post-doctoral researchers seeking training in integrative whole organ systems sciences. The fund is currently supported by Abbott Laboratories, Merck Research Laboratories, Pfizer and Wyeth Research. The goal is to help augment developing programs (see above) that provide training of students in this field. For application information, visit: http://www.aspet.org/public/public_affairs/pa_ioss.html

Schedule of National Animal Welfare Education Programs. Workshops and Conferences
View: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-08-043.html

FASEB NEWS
For FASEB biweekly news from Capitol Hill: http://opa.faseb.org/ . Also available are links to the FASEB FY2009 Funding Recommendations for Science Agencies and the launch of FASEB’s new voter education initiative, ScienceCures.


February 2008
ASPET Government and Public Affairs Report Appropriations Update

NIH  Appropriations
Congress at last finished its work on the FY’08 budget combining eleven appropriations bills into one large omnibus legislative bill. NIH receives $28,942 billion in FY’08. This amounts to a $329 million increase; however NIH is being asked to transfer $196 million to the Global Aids Fund. Taking into account the transfer, NIH’s increase is just 0.46%, a $133 million increase.

NIGMS Renews RFA for Short Courses in Integrative and Organ Systems Pharmacology
Details: http://www.aspet.org/public/public_affairs/pa_ioss.html or http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-08-010.html.  All inquiries should be directed to Richard T. Okita, Ph.D.- Program Director, NIGMS - Tel: 301-594-3827 - Fax: 301-480-2802 - okitar@nigms.nih.gov.

ASPET-IOSS Fund Application Guidelines
The ASPET-IOSS Fund was created to provide support for graduate students and post-doctoral researchers seeking training in integrative whole organ systems sciences. The fund is currently supported by Abbott Laboratories, Merck Research Laboratories, Pfizer and Wyeth Research. The goal is to help augment developing programs (see above) that provide training of students in this field. For application information, visit: http://www.aspet.org/public/public_affairs/pa_ioss.html

FDA Coalitions Merge
Two organizations dedicated to advocating for greater congressional funding levels for the FDA have merged to form the Alliance for a Stronger FDA. ASPET remains a member of this organization (previous affiliation was the former FDA Alliance) and has assisted in various grassroots efforts. The new alliance hopes to deliver more consistent messages to the public, media, congress, and the Administration. The Alliance for a Stronger FDA website is expected to be updated in the next few days: www.StrengthenFDA.org

AAMC Symposium: The Scientific Basis of Influence and Reciprocity
AAMC has published the findings of a symposium on the scientific basis of influence and reciprocity. The symposium, held in June 2007, summarized the latest evidence from neuroscience and the behavioral sciences that addresses the challenges to objectivity presented by gifts, favors, and influence in academic medicine. The symposium report is available for free online. View: http://www.aamc.org/reciprocity NIH Issues Revised Policy Statement on Public Access

Public Access
The National Institutes of Health (NIH) Jan. 11 issued a revised policy statement reflecting that compliance with the agency's "public access" rules is now required by statute, specifically the recent "Consolidated Appropriations Act of 2008." The legislation requires that all investigators funded by NIH ensure that an electronic version of their final, peer-reviewed manuscripts accepted for publication is submitted to the National Library of Medicine within 12 months of the official date of publication.

New NCCAM Director
Josephine P. Briggs, M.D., was named director of the National Center for Complementary and Alternative Medicine (NCCAM). An accomplished researcher and physician, Dr. Briggs brings a focus on translational research to the study of complementary and alternative medicine (CAM) to help build a fuller understanding of the usefulness and safety of CAM practices: Visit: http://nccam.nih.gov/about/director/

USP Announces 2008 Internships
USP has six summer internships that will begin May 18 and continue until mid-August at USP Headquarters in Rockville, MD.  The USP 2008 Summer Internship Program offers the opportunity for students to spend twelve weeks at USP working on a defined project that will assist USP in the areas of: Quality of Manufactured Medicines (including biologic and veterinary medicines),Quality of Compounded Medicines (human and veterinary), Quality of Food Ingredients and Dietary Supplements, Quality of Patient Care, Global Public Health, and Public Health Policy. Details: http://www.usp.org/aboutUSP/careers/internship.html.  The deadline for submitting applications is February 15, 2008.

ASPET Co-signs Letter to Texas Education Agency /Evolution Controversy
A letter co-signed by ASPET and other professional societies to the Texas Education Agency (TEA) expresses concern over the forced resignation of the agency’s Director of Science who was disciplined for sending an email advertising a talk by a proponent of evolution education. The Texas Education Agency said that the Director’s email implies that the TEA endorses the speaker’s position on a subject on which the agency must remain neutral. The letter states that “it is unacceptable for the TEA to remain neutral on the topic of evolution.” View: http://opa.faseb.org/pdf/2008/Evolution%20letter%20Castillo-Comer-Final.pdf.  See related link: http://opa.faseb.org/pages/PolicyIssues/sciencecoalition.htm for article concerning the coalition of scientific societies (includes ASPET) Evolution in Science Survey.

FASEB NEWS
For FASEB biweekly news from Capitol Hill: http://opa.faseb.org/.  Also available are links to the FASEB FY2009 Funding Recommendations for Science Agencies and the launch of FASEB’s new voter education initiative, ScienceCures.

Funding Opportunities
Drug Docking and Screening Data
http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-08-008.html

Assessment of Potential Cocaine Pharmacotherapies in Monkeys
http://grants.nih.gov/grants/guide/notice-files/NOT-DA-08-024.html




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