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Posting Policy:

Drug Metabolism Division members may post notifications of available positions or positions wanted on the Division web site at no charge. Non-members may also post notifications, but will be assessed a fee ($100) that must be paid prior to posting. All postings remain active for three months. All proceeds are used to support Drug Metabolism Division-sponsored educational and outreach programs. Contact Melissa Runge-Morris

m.runge-morris@wayne.edu for further information..

To post a job opportunity, CLICK HERE

Positions:

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Faculty position in Liver Pathobiology
The Department of Integrative Medical Sciences invites applications for a tenure track faculty position (rank commensurate with experience). Applicants must have 3 to 5 years postdoctoral experience and are expected to have a strong record of research productivity and potential for extramural grant support. The successful candidate will have research expertise to complement existing faculty research focused on lipid metabolism, cytochrome P450s, nuclear receptors and cell signaling in the liver and intestinal systems as it relates to liver diseases and diabetes. Primary teaching responsibilities will be in metabolic pathways and regulation, molecular biology, and genetics for medical, pharmacy and graduate students. We provide excellent core facilities, start-up funds, and a competitive salary commensurate with rank. Please send curriculum vitae, statement of research plan and teaching experiences, and three letters of recommendation to: John Chiang, Ph.D., Chair, Faculty Search Committee, Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272-0095. E-mail: jchiang@neoucom.edu.  NEOUCOM/P is an Equal Opportunity Affirmative Action Employer and is committed to diversity.  Posted 12-03-07
 

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Faculty Position, Department of Pharmacology, The University of Michigan
The University of Michigan, Department of Pharmacology is seeking outstanding scientists for a tenure-track ASSISTANT PROFESSOR position. We are especially looking for an outstanding scholar with exceptional potential to develop a vibrant research program that augments current department initiatives in Pharmacogenetics/genomics, Drug Metabolism, or Signal Transduction (see http://sitemaker.umich.edu/pharmacology/faculty_listing for faculty interests). Qualifications include a Ph.D. in Pharmacology or a related discipline and/or M.D. degree, 3-5 years of postdoctoral experience, and research accomplishments as evidenced by scholarly contributions to the literature.
The successful candidate will join a dynamic, diverse, and collaborative department in a Top 10 Medical School in a university setting with superb opportunities for career development. The quality of life in Ann Arbor is outstanding. The combination of a large, major research university and a small, safe, family-oriented community make Ann Arbor an ideal environment to develop an academic and research career. Ann Arbor also offers an outstanding combination of sports, recreation, and cultural events.
Faculty members are expected to establish a highly visible externally funded research program and to excel in teaching medical students and other health professionals, as well as graduate and postdoctoral students. An attractive startup package including excellent laboratory facilities and generous startup funds will be available.
Send your CV, a two- to four-page summary of your research and future plans, and details of your teaching experience. Three letters of recommendation should also be sent.
Address all correspondence to: Chair, Pharmacology Search Committee, Department of Pharmacology, University of Michigan Medical School, 2301 MSRB III, 1150 West Medical Center Dr., Ann Arbor, MI 48109-5632. Application materials may also be sent electronically to: pharmsearch@umich.edu.

The University of Michigan is an Affirmative Action/Equal Opportunity Employer. Applications from qualified women, minorities and/or disabled individuals are encouraged.  Posted 11-14-07

 

32 Opportunities from Pfizer
 Posted 7-24-07

When does research become answers?

Touching the lives of millions of people everywhere. Reaching beyond the ordinary to make an impact on something greater than the bottom line. Playing a key role in some of the most critical issues facing healthcare today.

We are Pfizer Global Research & Development (PGRD), the largest pharmaceutical R&D organization in the world. As Pfizer’s visionary discovery and development division, innovation shapes our strategy, defines our purpose and governs every facet of our operations - from the research and development that leads to pharmaceutical breakthroughs to the way we respond to the changing marketplace.

Our emphasis on innovation has enabled us to bring to market a wide range of outstanding medicines, such as Lipitor, Zithromax, Viracept, Zoloft, Viagra and our newest smoking cessation medicine, Chantix. But we recognize that there is much, much more work to be done, and we look forward to conquering the challenges facing global healthcare. Toda, our research pipeline spans many therapeutic areas and research projects and we’re committed to bringing even more miracles to the marketplace. Here, we imagine that our world can be a healthier and happier place for all.

Together, we will turn research into answers.

We Currently Have The Following Opportunities:

bulletPDM CNS Associate Director/Director (M2/M3)
This position involves strategic leadership and supervision of a group of scientists providing ADME support for the CNS portfolio, Position Purpose Scientific and organizational leadership of a team of therapeutic area principal investigators and associated lab staff responsible for the identification and prosecution of PDM strategies spanning the discovery and development continuum from therapeutic idea through loss of exclusivity (LOE) for CNS programs. The PDM operational responsibilities of this role include direct responsibility for operational excellence of all PDM efforts in a portion of the CNS therapeutic area. The role will need to have proven ability to develop strong partnerships/relationships across groups including experience working within a matrix management environment to optimize synergy between groups including dedicated PDM CNS bioanalytical resources.

The candidate will partner effectively across the R&D lines in Groton and the global PDM to ensure strategic and tactical alignment identify and champion opportunities for continuous improvement in productivity and quality in PDM, and will proactively lead and influence the People agenda for the PDM CNS groups and across Groton PDM, including effective performance management, talent development and building diversity Be an engaged contributor to Groton PDM extended leadership and Groton CNS Site leadership.

This position requires a PhD or equivalent in pharmaceutical sciences, biology, chemistry or a related field of research. Education/training in management and leadership skills preferred. 2. Additionally, a minimum of 8 years R&D experience in ADME science areas with specific experience in the application of PDM sciences and portfolio management from therapeutic idea through loss of exclusivity is expected, as is a record of managerial/supervisory and leadership excellence. Intimate knowledge of the application of PDM science to the progression of discovery projects, and the application of PDM science to development of compounds through loss of exclusivity is expected. Integration of knowledge into effective strategies across the discovery/development continuum is required. The position requires a practical working knowledge of study conduct and technical challenges associated with PDM. Job Requisition #: 70825, Groton, CT.  To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletPKPD Modeling & Simulation Specialist
Responsibilities include providing pre-clinical PK/PD expertise and leadership to a variety of drug discovery and development programmes. That means having strategic input into pre-clinical discovery and development plans; designing and interpreting pharmacokinetic and pharmacodynamic studies, analysing PK/PD data using state-of-the-art approaches and techniques, and communicating the results. This position works closely with colleagues from preclinical PK/PD groups at other Pfizer research centres across the globe. In addition, it involves forging collaborative relationships with specialists and groups outside the organization, as well as partnering with colleagues from clinical PK/PD and Translational Medicine to ensure Pfizer’s position as a leading light in the use of numerical approaches to support drug development strategies.

The qualified candidate will have a PhD with PK/PD experience and an impressive industry or academic record, a demonstrable interest and relevant experience in modeling and simulation methods applied to biological data is essential. Job Requisition #: 61060, Sandwich, UK.  To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletADME Associate/Sr Associate Scientist (R1/R2)
The qualified candidate will operate within the Pharmacokinetics, Dynamics and Metabolism (PDM) group in a Discovery project team setting and provide Discovery ADME support for one of the therapeutic areas (CNS-central nervous system, CVMED-cardiovascular, metabolic and endocrine disorders and AB-antibacterials). The primary focus of this laboratory based position will be contributing towards the execution of in vitro and in vivo studies characterizing the absorption, distribution, metabolism and elimination (ADME) attributes of new chemical entity’s (NCE’s). This individual will apply these assays to PK/ADME and PK-PD studies of drug candidates to support achievement of critical milestones, culminating in nomination of NCE’s for clinical development.

The qualified candidate will have an educational background in chemistry, biology, biochemistry or related discipline, a BS with 1-3 years relevant experience, a demonstrated ability to work with information technology systems/tools and databases (eg, WATSON, Galileo, RGate, Spotfire, etc), and technical skills associated with the conduct of in vitro ADME studies (e.g., microsomes, hepatocytes, protein binding). Job Requisition #: 65079, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletHit-to-Lead Associate/Sr Associate Scientist (R1/R2)
Conduct in vitro/in vivo and in silico drug metabolism experiments in support of projects in the hit-to-lead stage. Functions will include but are not limited to: 1) Conduct of biochemical enzymology studies and other in vitro ADME experiments, 2) Conduct data visualization, mining, in silico analysis, and aid in data interpretation, 3) Communication of data to scientific leader and project teams, entry of results into databases, and write up data in the form of study reports, and sections of lead development project operating plans.

The ideal candidate will have a BA/BS in chemistry/biology or related field, strong computer skills and experience in LC/MS and chromatography, pharmacokinetic, and drug metabolism techniques (microsomes, hepatocytes, and recombinant enzymes, protein binding) are desirable. Job Requisition #: 65084, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletADME Bench Scientist - Sr Scientist (R3/R4)
The qualified candidate will operate within the Pharmacokinetics, Dynamics and Metabolism (PDM) group in a Discovery project team setting and provide Discovery ADME support for one of the therapeutic areas (CNS-central nervous system, CVMED-cardiovascular, metabolic and endocrine disorders and AB-antibacterials). The primary focus of this laboratory based position will be contributing towards the execution of in vitro and in vivo studies characterizing the absorption, distribution, metabolism and elimination (ADME) attributes of new chemical entity’s (NCE’s). This individual will apply these assays to PK/ADME and PK-PD studies of drug candidates to support achievement of critical milestones, culminating in nomination of NCE’s for clinical development.

The qualified candidate will have an educational background in chemistry, biology, biochemistry or related discipline, a BS with over 4 years relevant experience within a drug metabolism research environment, a demonstrated ability to work with information technology systems/tools and databases (eg, WATSON, Galileo, RGate, Spotfire, etc), strong technical skills associated with the development and conduct of in vitro drug metabolism and disposition studies (e.g., microsomes, hepatocytes,protein binding), and an ability to interpret both in vitro and vivo ADME studies resulting from understanding and application of pharmacokinetic principles. Job Requisition #: 65098, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletDiscovery Biologics Bench Scientist (R3-R4)
The individual will operate in a Discovery project team setting and provide Discovery ADME support for biotherapeutics. The individual will be responsible for independent development, characterization and application of quantitative bioanalytical methods for candidate biopharmaceutical drugs in biological matrices using a range of potential assays including immunoassays (e.g. ELISA, RIA, etc), mass spectrometry-based assays and cell-based assays, such as flow cytometry. The individual will be involved with recommending the optimal bioanalytical method for a particular biopharmaceutical compound, based on knowledge of planned studies. This individual will apply these assays to PK/ADME and PK-PD studies of biopharmaceutical drug candidates to support achievement of critical milestones, culminating in Candidate nomination. This individual will conduct sample analysis to support the indicated PK and PK-PD studies, be responsible for data collection and reporting, and contribute to interpretation of experimental results.

The qualified candidate will have a BS or MS with major in Biology, Immunology, Chemistry and Biochemistry or related discipline, 5 years relevant experience in bioanalytical or PK laboratory at pharmaceutical or biotechnology industry or CRO. The successful candidate should be experienced in the area of bioanalysis, preferably with some experience in bioanalysis of biologics. Experience with PK/ADME work required for more senior roles. Job Requisition #: 65132, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletDiscovery Biologics Bench Scientist (R3-R4)
The individual will operate in a Discovery project team setting and provide Discovery ADME support for biotherapeutics. The individual will be responsible for independent development, characterization and application of quantitative bioanalytical methods for candidate biopharmaceutical drugs in biological matrices using a range of potential assays including immunoassays (e.g. ELISA, RIA, etc), mass spectrometry-based assays and cell-based assays, such as flow cytometry. The individual will be involved with recommending the optimal bioanalytical method for a particular biopharmaceutical compound, based on knowledge of planned studies. This individual will apply these assays to PK/ADME and PK-PD studies of biopharmaceutical drug candidates to support achievement of critical milestones, culminating in Candidate nomination. This individual will conduct sample analysis to support the indicated PK and PK-PD studies, be responsible for data collection and reporting, and contribute to interpretation of experimental results.

The qualified candidate will have a BS or MS with major in Biology, Immunology, Chemistry and Biochemistry or related discipline, 5 years relevant experience in bioanalytical or PK laboratory at pharmaceutical or biotechnology industry or CRO. The successful candidate should be experienced in the area of bioanalysis, preferably with some experience in bioanalysis of biologics. Experience with PK/ADME work required for more senior roles. Job Requisition #: 65132, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletBiomarker/Biologics Bioanalytical Leader (R7/R8)
Responsibilities include the quantitative analysis of peptides and small molecules identified as novel biomarkers. Successful job performance includes development, characterization, & implementation of appropriate extraction and purification techniques (e.g., protein precipitation, liquid-liquid extraction and SPE), implementation and validation of LC/MS, LC/MS/MS, and/or immunoanalytical methodology. Routine use of HPLC equipment, triple quadrupole MS/MS technology, liquid handling systems, immunoanalytical platforms, and Watson LIMS are required. Position requires expertise in biological sample handling and preparation, and laboratory automation. Other responsibilities include independent planning of laboratory activities, understanding and influencing therapeutic area biomarker strategies to use biomarkers in scientific decision-making. Successful performance includes leadership in all phases of bioanalytical laboratory operations.
The qualified candidate will have a Bachelors Degree in a relevant field (Chemistry, Analytical Chemistry, Biology) with at least 10 years experience; or a Masters degree with at least 6 years experience; or a Doctorate with at least 4 years experience in relevant scientific field with industrial experience, significant experience in development, characterization, and implementation of quantitative analytical assays (mass spectrometry & immunoanalytical) using wet chemical sample preparation methods and instrumentation, experience working in a matrix scientific discipline and team. Job Requisition #: 65266, La Jolla, CA
To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletPK/PD (R4 –R5)
You will be responsible for collaborating within the PDM PK/PD function to establish PK/PD approaches as a core competency for PDM in alignment with PGRD PK/PD best practices. This will include modeling using NONMEM and/or other appropriate simulation/data visualization tools; designing, conducting, analyzing, and interpreting PK/PD studies in collaboration with and in support of other disciplines to build predictive and translatable preclinical PK/PD models; using these models to enable Discovery projects to make appropriate predictions of clinical dose regimens based on the NCE’s PK/PD characteristics and desired therapeutic index; and the technical application of practical PK/PD modeling to preclinical in vivo efficacy models/data in support of drug discovery programs. The candidate will also be expected to influence PDM and partner line scientists to optimize in vivo efficacy models to improve the quality, productiveness, & translatability of PK/PD models/data, where appropriate. Translating knowledge of emerging literature and science in the PK/PD area into new and innovative methods will be expected.

The qualified R4 candidate will have a Ph.D. with 1-3 years, M.S. with 4-6 years, or B.S. with 7-9 years experience in pharmacoki¬netics, pharmaceutics, or a related field with previous experience in PK/PD or ADME/PK modeling of NCEs/drugs. The qualified R5 candidate will have a Ph.D. with 3-5 years, M.S. with 6-8 years, or B.S. with 9-11 years experience in same. Candidates will also have proficiency working with databases, web based applications and other information technology tools; advanced knowledge of ADME, PK, and PK/PD principles and sound understanding of the role of contemporary PDM science in drug discovery and development; a demonstrated track record of impact in using PK/PD knowledge to advance drug discovery/development projects; and previous ex¬perience as preclinical PK/PD modeler in a drug-discovery environment; and advanced hands-on knowledge of NONMEM or equiva¬lent PK/PD software package (e.g. Splus, SAS). Outstanding oral/written communication skills are mandatory, as well as a proven record of building strong collaborations and effective interfaces within PDM and across research lines. Job Requisition#: 65272, St. Louis, MO

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletPK/PD Modeler (R6/R7)

This position will be responsible for collaborating within the PDM PK/PD function to establish PK/PD approaches as a core competency for PDM in alignment with PGRD PK/PD best practices. Modeling using NONMEM and/or other appropriate simulation/data visualization tools is expected. The candidate will design, plan, execute, analyze, and interpret PK/PD studies in collaboration with & support of other disciplines in PDM and across Pfizer Global R&D Discovery & clinical PK/PD lines (among others) to build predictive and translatable preclinical PK/PD models. The candidate will use these models to enable Discovery projects to make appropriate predictions of clinical dose regimens based on the NCE’s PK/PD characteristics and desired therapeutic index. A primary responsibility will be the technical application of practical PK/PD modeling to preclinical in vivo efficacy models/data in support of drug discovery programs. The candidate will also be expected to influence PDM and partner line scientists to optimize in vivo efficacy models to improve the quality, productiveness, & translatability of PK/PD models/data, where appropriate.

The qualified candidate will have a Ph.D. with 5-7 years, M.S. with 8-10 years, or B.S. with 11-13 years experience in pharmacokinetics, pharmaceutics, or a related field including previous experience in PK/PD or ADME/PK modeling of NCEs/drugs for R6 candidates, and a Ph.D. with at least 7 years, M.S. with at least 10 years, or B.S. with at least 13 years experience in pharmacokinetics, pharmaceutics, or a related field including previous experience in PK/PD or ADME/PK modeling of NCEs/drugs for R7 candidates. Job Requisition #: 65276, La Jolla, CA

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletPDM-PK/PD Sr Principal Scientist/Associate Research Fellow
You will be responsible for collaborating within the PDM PK/PD function to establish PK/PD approaches as a core competency for PDM in alignment with PGRD PK/PD best practices. This will include modeling using NONMEM and/or other appropriate simulation/data visualization tools; designing, conducting, analyzing, and interpreting PK/PD studies in collaboration with and in support of other disciplines to build predictive and translatable preclinical PK/PD models; using these models to enable Discovery projects to make appropriate predictions of clinical dose regimens based on the NCE’s PK/PD characteristics and desired therapeutic index; and the technical application of practical PK/PD modeling to preclinical in vivo efficacy models/data in support of drug discovery programs. The candidate will also be expected to influence PDM and partner line scientists to optimize in vivo efficacy models to improve the quality, productiveness, & translatability of PK/PD models/data, where appropriate.

The qualified R6 candidate will have a Ph.D. with 5-7 years, M.S. with 8-10 years, or B.S. with 11-13 years experience in pharmacoki¬netics, pharmaceutics, or a related field including previous experience in PK/PD or ADME/PK modeling of NCEs/drugs. The qualified R7 candidate will have a Ph.D. with 7 years, M.S. with 10 years, or B.S. with 13 years experience in the same areas. Candidates will also have proficiency working with databases, web based applications and other information technology tools; expert knowledge of ADME, PK, and PK/PD principles and sound understanding of the role of contemporary PDM science in drug discovery and develop¬ment; a demonstrated track record of impact in using PK/PD knowledge to advance drug discovery/development projects; at least 3 years experience as preclinical PK/PD modeler in a drug-discovery environment; and proficiency with of NONMEM or equivalent PK/PD software package (e.g. Splus, SAS). Translating knowledge of emerging literature and science in the PK/PD area into new and innovative methods and applying those methods to support discovery teams will be expected. Outstanding oral/written communica¬tion skills are mandatory, as well as a proven record of building strong collaborations and effective interfaces within PDM and across research lines. Job Requisition#: 65277, St. Louis, MO

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletBiomarker/Biologics Regulated Bioanalytical Scientist (R1/R2)
Job responsibilities include the quantitative analysis of peptides and small molecules identified as novel biomarkers in biological in vivo matrices. Successful job performance includes implementation of appropriate extraction and purification techniques (e.g., protein precipitation, liquid-liquid and solid phase extraction), implementation and validation of LC/MS, LC/MS/MS, and/or immunoanalytical methodology. Routine use of HPLC equipment, triple quadrupole MS/MS technology, liquid handling systems, immunoanalytical platforms, and Watson LIMS are required. Position requires expertise in biological sample handling and preparation, laboratory automation, and regulatory compliance.

The qualified candidate will have an Associate Degree in a relevant field (Chemistry, Analytical Chemistry, Biology), 0-3 years of experience, experience in quantitative analytical assays (mass spectrometry & immunoanalytical) using wet chemical sample preparation methods and instrumentation. Job Requisition #: 65294, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletBiomarker/Biologics Regulated Bioanalytical Scientist (R3/R4)
This is a bench position in the GLP Bioanalytical Group in Worldwide PDM. Job responsibilities include the quantitative analysis of peptides and small molecules identified as novel biomarkers in biological in vivo matrices. Successful job performance includes development, characterization, & implementation of appropriate extraction and purification techniques (e.g., protein precipitation, liquid-liquid and solid phase extraction), implementation and validation of LC/MS, LC/MS/MS, and/or immunoanalytical methodology. Routine use of HPLC equipment, triple quadrupole MS/MS technology, liquid handling systems, immunoanalytical platforms, and Watson LIMS are required. Position requires expertise in biological sample handling and preparation, laboratory automation, and regulatory compliance.

The qualified candidate will have a Bachelors Degree in a relevant field (Chemistry, Analytical Chemistry, Biology), 3-8 years of experience, significant experience in development, characterization, and validation of quantitative analytical assays (mass spectrometry & immunoanalytical) using wet chemical sample preparation methods and instrumentation. Job Requisition #: 65297, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletBiomarker/Biologics Regulated Bioanalytical Scientist (R5/R6)
You will be responsible for the quantitative analysis of peptides and small molecules identified as novel biomarkers in biological in vivo matrices. Successful job performance includes development, characterization, & implementation of appropriate extraction and purification techniques (e.g., protein precipitation, liquid-liquid and solid phase extraction), implementation and validation of LC/MS, LC/MS/MS, and/or immunoanalytical methodology. Routine use of HPLC equipment, triple quadrupole MS/MS technology, liquid handling systems, immunoanalytical platforms, and Watson LIMS are required. Track record of implementation and validation of novel analytical platforms and automation is required.

The qualified candidate will have a Bachelors Degree in a relevant field (Chemistry, Analytical Chemistry, Biology)with more than 10 years experience; or a Master’s degree with at least 4 years experience; or a Doctorate with at least 2 years experience in relevant scientific field with appropriate years of industrial experience, significant expertise in development, characterization, and validation of quantitative analytical assays (mass spectrometry & immunoanalytical) using wet chemical sample preparation methods and instrumentation, experience with bioanalytical assay validation & regulatory compliance. Job Requisition #: 65305, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletSmall Molecule Regulated Bioanalytical Scientist/Sr Assoc (R2/R3)
The primary role of the small molecule bioanalytical scientist (regulated bioanalysis) is to provide quality bioanalysis support for toxicology studies and clinical pharmacokinetic studies. The position requires the ability to perform bioanalytical LC/MS/MS method development and validation for drugs and their metabolites in various biological fluids; routine sample analysis to support GLP preclinical studies and early clinical studies in the timely fashion. The individual will be responsible for quality data review and bioanalytical report preparation. More senior roles may include providing technical guidance to support method transfer and assay trouble shooting at contract research organizations (CROs).
The qualified candidate will have a BS/MS Analytical Chemistry with 2+ years of relevant experience, independent development and validation of bioanalytical method for drugs and their metabolites in various biological fluids using LC/MS/MS, deep knowledge of the regulatory requirements and guidance for regulated bioanalysis, and hands-on experience with LC/MS/MS, laboratory automation, modern laboratory information systems (LIMS) and other analytical instruments. Job Requistion #: 65319, Groton, CT
To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletSmall Molecule Regulated Bioanalytical Scientist, Sr Scientist- Principal Scientist (R4/R5)

The primary role of the small molecule bioanalytical scientist (regulated bioanalysis) is to provide quality bioanalysis support for toxicology studies and clinical pharmacokinetic studies. The position requires the ability to perform bioanalytical LC/MS/MS method development and validation for drugs and their metabolites in various biological fluids; routine sample analysis to support GLP preclinical studies and early clinical studies in the timely fashion. The individual will be responsible for quality data review and bioanalytical report preparation. Additional responsibilities will include providing technical guidance to support method transfer and assay trouble shooting at contract research organizations (CROs).

The qualified candidate will conduct independent development and validation of bioanalytical method for drugs and their metabolites in various biological fluids using LC/MS/MS, deep knowledge and experience in the area of GLP and familiar with regulatory requirement on conducting regulated bioanalysis, hands-on experience with LC/MS/MS, laboratory automation, modern laboratory information systems (LIMS) and other analytical instruments. Job Requisition #: 65327, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletSmall Molecule Bioanalytical (R5/R6)

The primary role is to lead a team of scientists to provide quantitative analysis of drugs and metabolites from biological matrixes to support drug discovery programs. The successful candidate will champion new technologies and methodologies to add value and enable rapid decision making. The candidate will demonstrate the ability to mentor a high performance team where technical excellence, empowerment, career development and leadership at all levels are expected and fostered. Responsibilities include supervising the quantitative analysis of drugs and metabolites in biological matrices from in vitro and preclinical in vivo studies. Successful performance includes directing all phases of bioanalytical laboratory operation including the development and trouble shooting of appropriate extraction and purification techniques; development, characterization, and problem solving of HPLC, MS/MS, and automated sample liquid handling methodology; study sample analysis; and data interpretation.

The qualified candidate will have a PhD in analytical chemistry/related field or equivalent experience in industrial setting, experience with quantitative bioanalytical chemistry, including sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, and SPE) from biological matrices (e.g., serum, plasma, urine, and tissues), experience with HPLC, LC-MS/MS, and quantitative data analysis, interpretation, and presentation, a demonstrated record of developing partnerships in a matrix environment, leadership in technology development and implementation, and experience managing a group of at least two colleagues, 2+ years experience supervising, training, and developing analytical scientists. Job Requisition #: 65340, La Jolla, CA

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletEnvironmental Fate

The qualified candidate will operate within the Pharmacokinetics, Dynamics and Metabolism (PDM) group and support studies which assess the environmental impact of drugs and their metabolites. Duties will include but not limited to being esponsible for Environmental Science design, conduct and reporting of appropriate ecotoxicity studies (e.g. OECD) in support of regulatory EA/ERA filings for the Pfizer portfolio; duties will include contributions to the development of appropriate strategies and implementation of tests, management of studies, analysis of data, writing technical reports and presenting key data to internal colleagues; being responsible for interface with contract facilities in support of ecotoxicity testing and research activities and act as study monitor for such activities; taking a leadership role in developing and utilizing state of the art scientific approaches for novel ecotoxicity screens and coordinate QSAR activities laboratory based research to support the Pfizer portfolio, accomplished through in-house activities, collaborations with contact labs and through alliances with external Environmental Science consultants; present and publish key findings internally and externally; and being responsible for developing internal collaborations with key colleagues in partner lines such as drug safety, drug metabolism, regulatory.

The qualified candidate will have a PhD in Environmental Toxicology, Marine Biology or equivalent preferred, and a good understanding of pharmacological mechanisms of action; and standard OECD, TAD and NPDES methods. Job Requisition#: 65347, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletSmall Molecule Bioanalytical Leader
Serving as the head of the PDM Discovery Assay Technology group, you will be responsible and accountable for the successful bioanalytical and in vivo support of all of the PK studies conducted by PDM in support of discovery projects in St. Louis. This will include developing strategies and methodologies for the efficient determination of compounds PK properties in laboratory animals to support compound selection through CAN nomination; conducting PK studies in laboratory animals according to the highest ethical standards and the efficient determinations of drug concentrations in biological fluids from these experiments; and the definition and successful implementation of the PDM therapeutic area strategies.

The qualified candidate will have a degree in Chemistry, pharmaceutical sciences, or biology disciplines; at least 10 years R&D Experience with BS or at least 5 years R&D Experience with Ph.D.; experience in leading cross-functional drug discovery and/or development teams with responsibility and accountability for delivery of goals; intimate knowledge of the application of PDM science to the progression of discovery and development projects; and strong scientific expertise with in vitro and in vivo PDM research including bioanalytical chemistry. A record of leadership excellence as well as proven success in talent development, conflict management, effective team building and innovation management are required. Job Requisition#: 065395, St. Louis, MO

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletSmall Molecule Regulated Bioanalytical Leader (R6/R7)
The small molecule bioanalytical leader (regulated bioanalysis) and her/his group will provide GLP bioanalysis support for toxicology and clinical PK studies. Responsibilities: developing/validating LC/MS/MS assays for drugs and metabolites in biological matrices; support sample analysis for TK and clinical studies as needed; review and approve data and reports; ensure compliance with the regulations and SOPs; provide scientific and technical leadership to the group; proactively collaborate with partners and customers to achieve continuous process improvement. The person will be responsible for managing resources and studies timelines for his/her projects. The individual will be expected to provide expert scientific and technical leadership, mentoring and guidance to the staff, advancing bioanalytical science and technology, integrating existing and implementing new technologies into routine bioanalysis, including laboratory automation, robotics and novel detection, separation and sample preparation techniques.

The qualified candidate will have a PhD in Pharmaceutical Sciences, Analytical Chemistry or related discipline with 8+ years of experience or equivalent, expertise in GLP regulated LC/MS/MS bioanalysis, including laboratory automation, deep knowledge and experience in the area of GLP and familiar with regulatory requirement on conducting regulated bioanalysis. Job Requisition #: 65406, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletSmall Molecule Regulated Bioanalytical Leader, Principal Scientist-Senior Principal Scientist (R5/R6)
The small molecule bioanalytical leader (regulated bioanalysis) will provide GLP bioanalysis support for toxicology and clinical PK studies. Responsibilities: developing/validating LC/MS/MS assays for drugs and metabolites in biological matrices; support sample analysis for TK and clinical studies as needed; review and approve data and reports; ensure compliance with the regulations and SOPs; provide scientific and technical leadership to the group; proactively collaborate with partners and customers to achieve continuous process improvement.

The qualified candidate will have a PhD in Pharmaceutical Sciences, Analytical Chemistry or related discipline with 3+ years of experience or equivalent, strong expertise in GLP regulated LC/MS/MS bioanalysis, including laboratory automation, deep knowledge and experience in the area of GLP and familiar with regulatory requirement on conducting regulated bioanalysis. Job Requisition #: 65421, Groton, CT

To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers
 
bulletBiomarker/Biologics Bioanalytical Leader
You will be responsible for the quantitative analysis of peptides and small molecules identified as novel biomarkers. This will include development, characterization, & implementation of appropriate extraction and purification techniques (e.g., protein precipitation, liquid-liquid extraction and SPE); implementation and validation of LC/MS, LC/MS/MS, and/or immunoanalytical methodology; and routine use of HPLC equipment, triple quadrupole MS/MS technology, liquid handling systems, immunoanalytical platforms, and Watson LIMS. Other responsibilities include independent planning of laboratory activities; understanding and influencing therapeutic area biomarker strategies to use biomarkers in scientific decision-making; and leadership in all phases of bioanalytical laboratory operations.

The qualified candidate will have a minimum of a Bachelors Degree in relevant field (Doctorate desirable); industrial experience in a relevant field (Bachelor - 10 years, Master - 8 years, or Doctorate Degree - 5 years); significant experience in development, characterization, and implementation of quantitative analytical assays using wet chemical sample preparation methods and instrumentation; excellent communication and leadership skills; experience developing partnerships in a matrix environment; and the ability to influence project strategies. Candidate must have experience training and developing analytical scientists in a team environment. Publications in peer-reviewed scientific journals and external and internal presentations are expected. Job Requisition#: 65436, St. Louis, MO

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bulletBiomarker/Biologics Bioanalytical Lead (R6/R7)
The qualified candidate will operate within the Pharmacokinetics, Dynamics and Metabolism (PDM) group in a Discovery project team setting and provide Biomarker Bioanalytical support for several therapeutic areas (CNS-central nervous system, CVMED-cardiovascular, metabolic and endocrine disorders and AB-antibacterials). Responsibilities include the quantitative analysis of peptides and small molecules identified as novel biomarkers. Successful job performance includes development, characterization, & implementation of appropriate extraction and purification techniques (e.g., protein precipitation, liquid-liquid extraction and SPE), implementation and validation of LC/MS, LC/MS/MS, and/or immunoanalytical methodology. Routine use of HPLC equipment, triple quadrupole MS/MS technology, liquid handling systems, immunoanalytical platforms, and Watson LIMS are required. Position requires expertise in biological sample handling and preparation, and laboratory automation.

The qualified candidate will have a Bachelors with at least 10 years experience or a Masters with at least 6 years experience, or Doctorate Degree with at least 4 years experience in relevant scientific field with industrial experience, significant experience in development, characterization, and implementation of quantitative analytical assays (mass spectrometry & immunoanalytical) using wet chemical sample preparation methods and instrumentation. Job Requisition #: 65437, Groton, CT

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bulletADME Project Expert/TA Project Leader
This role includes: requesting and interpreting data provided by other groups in PDM, liasing with project team members on compound progression, issue identification and providing direction to the project with proven ability in independent decision making. You'll also represent PDM at a number of governance bodies and providing guidance and input on both projects and TA strategy / goals. Within TA group, you'll have responsibility for the progression of TA compounds post-LD nomination and will implement studies, risk mitigation strategies and documentation required in PDM to progress programmes out to key go/no go decision point in development (up to PoC). You could also act as point of accountability for assigned Development projects post PoC out to registration. Within Exploratory Research group, you'll ahve responsibility for progression of exploratory projects within a given TA from SDS to LD-POP drawing together the emerging chemical and biological picture to identify PDM issues and develop a risk mitigation strategy. You'll work with PDM TA Heads and Exploratory groups and leaders with Research to present develop a plan at the first PRISM meeting before handing over to the project team.

The qualified candidate will have a BSc, MSc or PhD level education with extensive practical knowledge of all areas of ADME and integration of data to determine compound progression, experience in drug discovery / development up to First in Human, a broad knowledge of all areas ADME Science and drug discovery and development and knowledge of pharmacokinetics and use of appropriate tools (eg. Watson). Job Requisition #: 65594, Sandwich, UK

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bulletSenior GLP Small Molecule Bioanalyst
Responsibilities involve developing and characterization of new fit-for-purpose methods for the analysis of pharmaceutical compounds in biological matrices, and provide high quality concentration data in support of clinical and non-clinical GLP safety studies. Main duties include providing appropriate training/knowledge transfer to the group, either using in-house expertise or recommending attendance at outside facilities, providing scientific direction to other staff, providing efficient, timely bioanalytical support for all assigned projects for GLP and clinical studies, encouraging the development of state of the art assays that are used in support of regulatory studies, troubleshooting instrumentation to ensure high robustness and efficient use of MS resources and other analytical platforms, ensuring all work activities are carried out in compliance with Good Laboratory Practices (GLP, GCLP, GCP) and to promote high level of safe working practices within the laboratory, implementing efficient working practices by providing adequate training and constructive feedback to the group to help them improve performance and productivity, improving turnaround of data by encouraging the development of sensitive analytical methods that are simple and easy to run, that involve the use of both automation capabilities and on-line sample preparation techniques available in the group (e.g. micro Turbulent Flow, Symbiosis, Parallel LC, Hamilton robotics), keeping abreast of current and advancing technologies in the area of bioanalysis, so that state-of-the-art instrumentation is available to optimise efficiency of assay development, sample analysis and issuing of reports, and facilitating interactions with other bioanalytical groups to ensure common practices are encouraged and technology effectively exchanged.
The qualified candidate will have a BSc. or MSc in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or Life Sciences based subject or equivalent, practical bioanalytical chemistry experience and up to date experience of modern bioanalytical technology within a GLP environment, a breadth of knowledge of analytical techniques (LC/MS, LC/UV, Fluorescence and electrochemical detection), familiarity with laboratory software packages such as Watson LIMS, Sciex Analyst and Hamilton Vector to enter study design and manage data acquisition, processing and storage is desirable. Job Requisition #: 65676, Sandwich, UK. To learn more about our people, our products, and our plans for the future, visit www.pfizer.com/careers

 
bulletPDM Strategic Sourcing Lead
This position is a centralized, global leadership role to develop and manage a coordinated business plan to strategically utilize external resources, systems and tools that to maximize WW PDM’s overall operational efficiency and effectiveness. The successful candidate will be responsible for establishing and developing external vendor relationships on behalf of WWPDM, reporting to the Global Lead, WWPDM Regulatory Bioanalytical, Compliance and Strategic Sourcing, acting as a member of/representative to appropriate PGRD-wide operations councils, task forces and management bodies which oversee external cross-line business strategies and process improvements. Additionally, this position is likely to interface with outside consultant organizations, as well as with HR, Finance, SMG and Research Informatics business partners, will act as a leader of PDM professionals responsible for developing and managing a coordinated business plan to strategically utilize external resources, systems and tools that to maximize WW PDM’s overall operational efficiency and effectiveness, and will partner with Head of Research, Asia (excluding Japan) and Procurement for external business development.

In addition, this position is responsible for developing, implementing and managing WWPDM strategic sourcing strategy including vendor capability and capacity development in near and far shore markets, developing and implementing business change management and process improvement strategies to achieve performance excellence across PGRD, and is expected to drive change and lead transition management for continuous improvement initiatives necessary to ensure outstanding business performance within WW PDM. The position will be responsible for alignment of resources to develop and implement organizational strategies, analyses and modeling aimed at improving WW PDM performance and maximization of resource utilization, and is expected to monitor latest trends in related and un-related industries to determine opportunities for improvement in PDM.

Qualifications include a BS/MS or PhD in PDM relevant science, Business Operations, or related field, and training in leadership skills, supervisory skills and management skills, while an MBA or equivalent training/relevant business experiences in business administration would be an advantage.

The candidate should have 5-10 years of pharmaceutical or biotechnology industry involved in drug discovery and development, in-depth knowledge and experience of ADMET science, technology, systems and process, experience and knowledge of Good Laboratory Practices and internal and external regulatory audit/inspections, and experience in business operations and project management and working in a matrix team. Job Requisition #: 65708, Groton, CT

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bulletHit-to-Lead Scientist, Scientist - Sr Scientist (R3/R4)
Design and conduct in vitro/in vivo and in silico drug metabolism experiments in support of projects in the hit-to-lead stage. Functions will include but are not limited to: 1) Design and conduct biochemical enzymology studies and other in vitro ADME experiments, 2) Conduct data visualization, mining, in silico analysis, and data interpretation, 3) Communication of data to scientific leader and project teams and act as a technical resource for interpretation of in vitro ADME data, entry of results into databases, and write up data in the form of study reports, and sections of lead development project operating plans.

The qualified candidate will have a BA/BS in chemistry/biology or related field, experience in LC/MS and chromatography, pharmacokinetic, and drug metabolism techniques (microsomes, hepatocytes, and recombinant enzymes, protein binding) is highly desirable. Job Requisition #: 68788, Groton, CT

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bulletPDM Biologics, Principal-Senior Principal Scientist (R5/R6)

You will supervise 2-3 lab associates. The individual and her/his group will provide quality bioanalytical support to various preclinical toxicology and clinical PK studies for candidate pharmaceutical drugs in biological matrices using immunoassays (e.g. ELISA, RIA, etc). This individual is expected to serve as an expert in performing bioanalytical method development, validation, trouble shooting, sample analysis and reporting as well as in development and implementation of new SOPs and revision of current SOPs in relevant areas. This individual is responsible for choosing the most appropriate methodology and technique; training, directing, supervising bioanalysts on method development, validation, trouble shooting, sample analysis and reporting and appropriate documentation according to regulatory guidelines; coordinating resources to ensure timely study support; maintaining and improving regulatory compliance of data and supporting documentation and laboratory work.

The qualified candidate will have a PhD or equivalent in Biological Sciences, Pharmaceutical Sciences or related field, at least 3–5 years of relevant experience, an acknowledged expertise in quantitative immunoassays, analytical data interpretation and method development and validation, a good knowledge of Good Laboratory Practices (GLP’s) and Standard Operating Procedures (SOP’s), proficiency in current technology used for immunoassays (e.g. ELISA, RIA, etc) and laboratory automation and LIMS, and be able to trouble shoot routine analytical problems. Job Requisition #: 68801, Groton, CT

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bulletHit-to-Lead, Sr Principal Scientist/Associate Research Fellow (R6/R7)

The role is accountable for the successful development and implementation of novel ADME (absorption, distribution, metabolism and excretion) approaches for the support of projects in the early discovery stage (Hit-to-Lead). These approaches would include implementation of in silico models as well as establishing correlations between physicochemical properties and ADME. This individual will be responsible for the daily operational and scientific leadership of a laboratory dedicated to utilizing ADME tools, to advance the early portfolio. Early incorporation of ADME parameters is critical for the successful progression of projects and reduced attrition due to ADME issues. This individual will be part of the Lead Generation Group (LGG) with the mission to define and implement new paradigms for PDM (Pharmacokinetics, Dynamics and Metabolism) support of early discovery projects.

The qualified candidate will have a PhD or equivalent in chemistry, pharmaceutical sciences or biology disciplines – e.g. biochemistry, analytical chemistry, pharmaceutical chemistry, pharmaceutical sciences, 4-6 years experience in the pharmaceutical industry with a well established track record on the utilization of in vitro ADME models to support drug discovery projects using innovative approaches, knowledge of incorporation of ADME attributes in chemical libraries in early drug discovery. Job Requisition #: 68859, Groton, CT

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bulletIn Vitro ADME Sr Scientist/Principal Scientist (R4/R5)
Primary responsibilities include supporting drug discovery and development by using ADME technology to provide decision-driving information working with teams to understand issues and formulate strategies to address issues, coordinate, designing and performing in vitro ADME studies as needed, providing education and clear communication of findings and conclusions, establishing and furthering in vivo – in vitro correlations / relationships to aid drug discovery and development efforts and to address knowledge gaps, providing rationale, evaluation and implementation for new in vitro ADME technology, broadening interest in ADME sciences and insight into future directions in this field, and working to support global PDM initiatives as needed.

The qualified candidate will have a M.S./Ph.D. in biochemistry, biology or related field, 5-7 years (MS), 0-3 years (PhD) working in an industrial or academic laboratory with primary focus on studying drug disposition (ADME), a depth of scientific, technical and application ability with in vitro ADME assays commensurate with current experts in the field as illustrated by an established publication record, a strong understanding of ADME concepts. Job Requisition #: 69482, Groton, CT

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bulletIn Vitro ADME Sr Principal Scientist/Associate Research Fellow (R6/7)

The qualified candidate will be highly involved in the utilization and advancement of in vitro ADME technology to support drug discovery and development efforts. The qualified candidate will be an effective member of the ADME Technology Group (ATG), which has as its mission continuous advancement of in vitro ADME end points (e.g., metabolic stability, DDI, permeability/absorption and transporters) towards greater in vivo predictability as its mission. The ATG group is an integral part of the department of Pharmacokinetics, Dynamics & Metabolism (PDM) and works closely with PDM colleagues as well as colleagues in other lines.

The qualified candidate will have a Ph.D. in biochemistry, biology or related field, 7+ years working in an industrial or academic laboratory with primary focus on studying drug disposition (ADME), a depth of scientific, technical and application ability with ADME concepts and in vitro ADME assays and technology commensurate with current experts in the field as illustrated by an extensive publication record and an established track record of significantly influencing the portfolio, expertise in developing in vitro – in vivo correlations, experienced in use and practical application of kinetic modeling software. Job Requisition #: 69483, Groton, CT

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bulletPK/PD Modeler Leader (R7/R8) 
The PK/PD leader will lead the establishment of PK/PD approaches as a core competency for preclinical research in line with the PGRD PK/PD best practice recommendations. This role will include collaborating with Therapeutic Area Leadership in Pharmacokinetics, Dynamics & Metabolism (PDM), Discovery Biology, the clinical PK/PD group and others to assure that translatable preclinical PK/PD models are developed and implemented at the site and on a global basis. This individual will provide strategic leadership at the site and globally in identifying, implementing and maintaining state of the art data acquisition, modeling, reporting, and archiving environment. A key aspect of this role will be assure that state of the art experimental and data analysis/reporting methods are implemented on a global basis, through active participation as a member of the PDM Global PK/PD Working Group. This individual will also serve as the PDM representative on the Translational Pharmacology Team at the site, assuring cross functional alignment and coordinated support of the application of PK/PD methods from early Discovery to clinical Proof of Concept. Serves in PDM as primary reviewer of Translational Research Plans across the portfolio of projects. Principal liaison with site Discovery Biology, Clinical PK/PD, Biometrics, and IT Departments to assure that optimal experimental, modeling and simulation approaches are applied. Serves as site PDM representative to the PDM Global PK/PD Working Group, and other global teams, as appropriate. Supervises site PK/PD Modeling group in planning, performing and reporting PK/PD analyses to support preclinical programs.

The qualified candidate will have a PhD (or equivalent experience) in the area of PK/PD, Pharmacology or Statistics, 5-10 years hands-on experience as PK/PD modeler; specific training in numerical and statistical aspects of analysis, experience with modeling and simulation of biomedical data, PK/PD experience obtained in a drug discovery environment, and experience with population approaches in PK and/or PK/PD. Job Requisition #: 69972, La Jolla, CA

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