Cytochrome P450

Division News
Meetings
Members
Exec. Committee
Journals
Job Opportunities
Research Links
Investigator's Webs
ASPET Home

Regulation

bullet

Developmental changes in P450 expression  (Compiled by Andrey L. Sukhodub) http://www.icgeb.trieste.it/~p450srv/P450_ageing.html

bullet

List of inducers of P450 enzymes http://medicine.iupui.edu/flockhart/

 

 Structure

bullet

X-ray structures, coordinates and models
bullet

http://metallo.scripps.edu/PROMISE/P450.html  

bullet

http://p450terp.swmed.edu/index.htm    (Bill Peterson)

bullet

Models
bullet

Structural models of P450s http://ws05.pc.chemie.tu-darmstadt.de/research/vrml/index.html (you must download “Cosmo Player” http://www.cai.com/cosmo/ to use this site)

bullet

Families of structural domains of P450-containing systems (Kirill N. Degtyarenko) http://www.icgeb.trieste.it/~p450srv/P450domains.html

bullet

Schematic representation of P450 systems domain structure (Kirill N. Degtyarenko) http://www.icgeb.trieste.it/~p450srv/domstr.html

bullet

Sequence similarities among P450s
bullet

Protein sequence alignments for P450 (David Nelson) http://drnelson.utmem.edu/Alignments.html

Function

bullet

Mechanism
bullet

NADPH-Cytochrome P450 Reductase (Todd Porter) http://www.uky.edu/Pharmacy/ps/porter/CPR.htm

bullet

Xenobiotic metabolism
bullet

Could include lists of compounds that are metabolized by specific P450 enzymes

bullet

Metabolism of endogenous compounds
bullet

To include endogenous compounds and the P450 enzymes responsible for their formation/degradation (e.g. bile acids, arachidonic acid metabolites, EETs and Hetes, steroids, cholesterol, etc.).

bullet

Enzyme-substrate selectivity
bullet

Steroid ligands of P450s http://www.icgeb.trieste.it/~p450srv/steroid_list.html

bullet

List of substrates for human P450 enzymes (David Flockhart) http://medicine.iupui.edu/flockhart/

bullet

Clinically used drugs metabolized by Cytochrome P450 http://medicine.iupui.edu/flockhart/
List of common inhibitors for human P450 enzymes http://medicine.iupui.edu/flockhart

 

Genomics

bullet

Gene Sequence
bullet

P450 gene databases (David Nelson) http://drnelson.utmem.edu/Databases.html

bullet

Arabidopsis and Drosophila P450 pages http://ag.arizona.edu/p450/

bullet

Gene Sequence Directory of P450s (Kirill N. Degtyarenko) http://www.icgeb.trieste.it/~p450srv/new/

bullet

Polymorphisms
bullet

Human Cytochrome P450 (CYP) Allele Nomenclature Committee http://www.imm.ki.se/CYPalleles/

bullet

Chromosomal Locations and Common Polymorphisms in Human P450 genes http://medicine.iupui.edu/flockhart